N,N-Bis(trimethylsilyl)formamide
- CAS NO.:15500-60-4
- Empirical Formula: C7H19NOSi2
- Molecular Weight: 189.4
- MDL number: MFCD00014849
- EINECS: 239-530-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:30
What is N,N-Bis(trimethylsilyl)formamide?
Physical properties
81–82 °C/20 mmHg; 154 °C/760 mmHg; mp 16–17 °C; n20 D 1.4388.
The Uses of N,N-Bis(trimethylsilyl)formamide
N,N-Bis(trimethylsilyl)formamide can be used as source of nucleophilic formamide and N-silylaldimine synthon.
N,N-Bis(trimethylsilyl)formamide (BSF) exists in the amide form with both silyl groups attached to the nitrogen atom. This is in contrast to most other bis(TMS)amides (e.g., bis(TMS)- acetamide), which favor the N,O-bis(TMS)imidate isomer. BSF behaves as an N-formamido nucleophile, reacting with the carbonyl group of aldehydes and activated ketones to give N-formyl-O-trimethylsilyl-N,O-acetals. Similarly, reaction with imines (or their precursors) can in some cases give N-formylN,N-acetals. BSF undergoes reactions with a range of other electrophiles including acid chlorides, chloroformate esters, and isocyanates to give a range of interesting products. When treated with organolithium nucleophiles, attack occurs at the carbonyl function, to provide N-silylaldimines after elimination of a silyloxy unit. Such imines are reported to undergo further reactions to give heterocycles. There are also reports of BSF acting as a silylating agent, to give silyl enol ethers, although it is not commonly used for this application.
Preparation
chlorotrimethylsilane was added at room temperature to a solution of formamide and triethylamine in dry benzene and the mixture was heated at reflux for 1 h. The reaction mixture was filtered, and the filtrate was evaporated to give a crude oil. This was purified by high-vacuum distillation to afford N,N-bis(trimethylsilyl)formamide (BSF) as an oil in 75% yield.
Properties of N,N-Bis(trimethylsilyl)formamide
Melting point: | 158 °C |
Boiling point: | 158 °C |
Density | 0.885 g/mL at 20 °C(lit.) |
refractive index | n |
Flash point: | 37 °C |
solubility | benzene, CCl4, CH2Cl2, CHCl3. |
pka | 0.16±0.70(Predicted) |
CAS DataBase Reference | 15500-60-4(CAS DataBase Reference) |
EPA Substance Registry System | Formamide, N,N-bis(trimethylsilyl)- (15500-60-4) |
Safety information for N,N-Bis(trimethylsilyl)formamide
Computed Descriptors for N,N-Bis(trimethylsilyl)formamide
New Products
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