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HomeProduct name listN-(Trimethylsilyl)acetamide

N-(Trimethylsilyl)acetamide

Synonym(s):TMS acetamide

  • CAS NO.:13435-12-6
  • Empirical Formula: C5H13NOSi
  • Molecular Weight: 131.25
  • MDL number: MFCD00008671
  • EINECS: 236-565-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-04-26 17:21:34
N-(Trimethylsilyl)acetamide Structural

What is N-(Trimethylsilyl)acetamide?

Chemical properties

WHITE TO YELLOWISH CRYSTALLINE MASS

The Uses of N-(Trimethylsilyl)acetamide

N-Trimethylsilylacetamide is a silylating agent used in organic synthesis. N-Trimethylsilylacetamide is used in the preparation of the antibacterial agent Cefdinir (C242670).

General Description

The efficiency of N-(Trimethylsilyl)acetamide (TMS acetamide) as allyl group scavenger and its compatibility with Fluorenylmethyloxycarbonyl chloride (Fmoc) protecting groups were studied.

Purification Methods

Distil the amide repeatedly in an inert atmosphere with all operations to be performed in an anhydrous atmosphere. In the presence of moisture, trimethylsilanol (b 31-34o/26mm) is formed and is a likely impurity (check by NMR). [Birkofer et al. Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]

Properties of N-(Trimethylsilyl)acetamide

Melting point: 46-49 °C(lit.)
Boiling point: 84 °C18 mm Hg(lit.)
Density  0.859±0.06 g/cm3(Predicted)
Flash point: 135 °F
storage temp.  Inert atmosphere,Room Temperature
solubility  Chloroform, DMSO, Methanol
pka 18.23±0.46(Predicted)
form  Crystalline Mass
color  White to yellow
Water Solubility  reacts
Sensitive  Moisture Sensitive
Hydrolytic Sensitivity 7: reacts slowly with moisture/water
BRN  741928
Stability: Moisture Sensitive
CAS DataBase Reference 13435-12-6(CAS DataBase Reference)
EPA Substance Registry System Acetamide, N-(trimethylsilyl)- (13435-12-6)

Safety information for N-(Trimethylsilyl)acetamide

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for N-(Trimethylsilyl)acetamide

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