Nifekalant hydrochloride
- CAS NO.:130656-51-8
- Empirical Formula: C19H28ClN5O5
- Molecular Weight: 441.91
- MDL number: MFCD00892243
- EINECS: 1533716-785-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 20:01:59
What is Nifekalant hydrochloride ?
Description
Nifekalant is a novel and pure class III anti-arrhythmic agent introduced in Japan as Shinbit injection for the treatment of serious ventricular arrhythmias. It can be synthesized in 3 steps with a final assembly of two ethanolamine blocks. Nifekalant is a non-selective blocker of myocardial repolarizing potassium currents and is completely devoid of any β-adrenergic blocking effect . In hearts from different species, Nifekalant significantly prolonged action potential duration, atrial and ventricular refractory periods in in situ and in isolation studies. In intact animals, hemodynamic parameters were not affected by doses up to 1 mg/kg. The specific characteristics of its voltage- and timedependent K+ current blockade might differentiate Nifekalant from other class III agents currently in use.
Description
Nifekalant is a class III antiarrhythmic agent that has been shown to be beneficial to initial resuscitation after cardiac arrest in clinical trials. It blocks the rapidly activating delayed rectifier potassium channel (IKr; IC50 = 10 μM). Nifekalant is also inhibits the human multidrug and toxin extrusion (MATE) transporter 1 (MATE1; IC50 = 6.5 μM).
Chemical properties
Yellow Solid
Originator
Mitsui (Japan)
The Uses of Nifekalant hydrochloride
Nifekalant Hydrochloride is a class III antiarrhythmic agent. Nifekalant Hydrochloride is used in the treatment of patients with extensive anterior infarction and severe ventricular dysfunction.
What are the applications of Application
Nifekalant Hydrochloride is an antiarrhythmic HERG inhibitor
Definition
ChEBI: Nifekalant hydrochloride is an amine. It contains a Nifekalant.
brand name
Shinbit
Properties of Nifekalant hydrochloride
Melting point: | 172-174° |
storage temp. | Refrigerator |
solubility | DMSO (Slightly, Heated), Methanol (Slightly, Heated), Water (Slightly) |
form | Solid |
pka | 7.05(at 25℃) |
color | Light Yellow to Yellow |
CAS DataBase Reference | 130656-51-8(CAS DataBase Reference) |
Safety information for Nifekalant hydrochloride
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Nifekalant hydrochloride
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