NAFAMOSTAT MESYLATE
- CAS NO.：81525-10-2
- Empirical Formula: C19H17N5O2
- Molecular Weight: 347.37
- MDL number: MFCD00866067
- EINECS: 1806241-263-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-03 15:02:28
What is NAFAMOSTAT MESYLATE?
Chemical properties
Odorless, bitter taste. Easily soluble in water, insoluble in methanol, ethanol or dimethylformamide, almost insoluble in ether, chloroform or acetone. Density: 1.39g/cm3; Boiling Point: 637.2°C; Flash Point: 339.1°C; Vapor Pressure: 3.9E-16mmHg.
The Uses of NAFAMOSTAT MESYLATE
Nafamostat is a non-peptide synthetic protease inhibitor with broad-spectrum and potent enzyme inhibition. For the treatment of acute pancreatitis. It can improve acute symptoms of acute pancreatitis, acute exacerbation of chronic pancreatitis, and post-traumatic pancreatitis.
Preparation
6-Bromo-2-naphthol reacts with copper cyanide in dimethylformamide to generate 6-cyano-2-naphthol, which is methanolylated and then aminolyzed to generate 6-amidino-2-naphthol , and finally esterification with p-guanidinobenzoic acid to generate nafamostat.
Definition
ChEBI: Nafamostat is a member of benzoic acids and a member of guanidines.
Properties of NAFAMOSTAT MESYLATE
| Boiling point: | 586.0±60.0 °C(Predicted) |
| Density | 1.39±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| solubility | Soluble in DMSO |
| form | Powder |
| pka | 11.30±0.30(Predicted) |
Safety information for NAFAMOSTAT MESYLATE
Computed Descriptors for NAFAMOSTAT MESYLATE
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin F Tubulysin D Tubulysin I Tubulysin A Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-Ethoxy-4-nitrobenzoic acid 2-(3,5-Di-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate Benzene butanoic acid, 2-hydroxy-3-iodo-, methyl ester 2-(2,4-Dibutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 6-bromo-4-methyl-2-propyl-1H-1,3-benzodiazole 5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-imidazole-4-carbonitrile 4-hydroxy-2-cyclopenten-1-oneRelated products of tetrahydrofuran
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