N6-CYCLOHEXYLADENOSINE

Synonym(s):CHA

CAS NO.：36396-99-3
Empirical Formula: C16H23N5O4
Molecular Weight: 349.38
MDL number: MFCD00036808
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is N6-CYCLOHEXYLADENOSINE?

Description

N⁶-Cyclohexyladenosine is an adenosine receptor agonist. It selectively binds to adenosine A₁ receptors in rat cortical membranes (IC₅₀ = 2.3 nM) over A₂ receptors in rat striatal membranes (IC₅₀ = 870 nM). N⁶-Cyclohexyladenosine decreases heart rate and increases coronary flow in a perfused working rat heart model ex vivo (EC₂₅s = 5 and 860 nM, respectively). In vivo, it decreases heart rate and blood pressure in normotensive rats (EC₂₅s = 2.4 and 4.2 μg/kg, respectively). N⁶-Cyclohexyladenosine (100 μM) induces sleep in rats when administered via basal forebrain infusion. N⁶-Cyclohexyladenosine also decreases locomotor activity in mice (ED₅₀ = 60 μg/kg, i.p.).

The Uses of N6-CYCLOHEXYLADENOSINE

N6-Cyclohexyladenosine is a derivative of Adenosine (A280400), and is used testing adenosine A1 and A2A receptor activation for pharmaceuticals such as antidepressants. N6-Cyclohexyladenosine also is used as a JAK2 inhibitor, blocking STAT3 signalling in human cancer cells.

What are the applications of Application

N6-Cyclohexyladenosine is a selective A1 adenosine receptor agonist

Biochem/physiol Actions

Selective A1 adenosine receptor agonist.

storage

Store at -20°C

Properties of N6-CYCLOHEXYLADENOSINE

Melting point:	182 - 184°C
Boiling point:	675.2±65.0 °C(Predicted)
Density	1.71±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
form	Solid
pka	13.12±0.70(Predicted)
color	White to Off-White
Stability:	Hygroscopic

Safety information for N6-CYCLOHEXYLADENOSINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H332:Acute toxicity,inhalation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.