6-METHYLAMINOPURINE 9-RIBOFURANOSIDE

Description

N⁶-Methyladenosine is an adenosine analog. It inhibits epinephrine-induced contraction of isolated guinea pig ileum and thoracic aorta when used at a concentration of 10 μM. N⁶-Methyladenosine (1 mg/kg, i.v.) decreases arterial blood pressure and renal blood flow and increases peripheral resistance in anesthetized dogs. It also inhibits tumor growth in the C3H/ST and C3HB/ST mouse models of spontaneous mammary adenocarcinomas. N⁶-Methyladenosine is also the most prevelant mRNA modification in eukaryotes and has roles in cell viability and development.

The Uses of 6-METHYLAMINOPURINE 9-RIBOFURANOSIDE

N6-Methyladenosine is the most common internal modification of eukaryotic mRNA. The result of this modification is specifically recognized mRNA in the cytoplasm which regulates mRNA stability.N6-Methyladenosine is made when a protein complex containin the writer enzyme METTL3 adds a methyl group to adenosine. Two different eraser enzymes ALKBH5 and FTO can remove a methyl group to turn m6A bach into adenosine.

Definition

ChEBI: A methyladenosine compound with one methyl group attached to N6 of the adenine nucleobase.