Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listN,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide

Synonym(s):BSA;N,O-Bis(trimethylsilyl)acetamide

  • CAS NO.:10416-59-8
  • Empirical Formula: C8H21NOSi2
  • Molecular Weight: 203.43
  • MDL number: MFCD00008270
  • EINECS: 233-892-7
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 18:52:02
N,O-Bis(trimethylsilyl)acetamide Structural

What is N,O-Bis(trimethylsilyl)acetamide?

Physical properties

bp 71–73°C/35 mmHg.

The Uses of N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide is a powerful silylating agent; reacts with a wide range of functional groups.
BSA was used to trimethylsilylate the hydroxyl group of 12 selectively to form in almost quantitative yield (eq 32).The presence of catalytic amounts (~0.02 equiv) of tetrabutylammonium fluoride (TBAF) significantly promoted the silylation of alcohols under mild conditions with high chemoselectivity, i.e., TBAF plays a role as a smooth silyl transfer catalyst from nitrogen to the hydroxyl group.

The Uses of N,O-Bis(trimethylsilyl)acetamide

Powerful silylation reagent for a wide range of functional groups under mild conditions

The Uses of N,O-Bis(trimethylsilyl)acetamide

N,O-bis(trimethylsilyl)-acetamide (BSA) is frequently used with TMCS as a catalyst to modify a variety of functional groups including carboxyl groups. In one novel application, BSA was used to measure carboxypeptidase activity by forming derivatives which could be determined by gas chromatography.BSA has been used to prepare derivatives of steroids and glucocorticoids.

Preparation

made by the reaction of acetamide with a large excess of chlorotrimethylsilane in the presence of triethylamine.

General Description

N,O-Bis(trimethylsilyl)acetamide is an excellent silylation reagent. For some sterically hindered primary or secondary nitro compounds, N,O-bis(trimethylsilyl)acetamide and BSTFA achieve better results than normal silylation conditions.

Purification Methods

Fractionate it through a spinning band column and collect liquid b 71-73o/35mm, and not higher because the main impurity MeCONHSiMe3 distils at b 105-107o/35mm. It is used for derivatising alcohols and sugars [Klebe et al. J Am Chem Soc 88 3390 1966, see Matsuo et al. Carbohydr Res 241 209 1993, Johnson Carbohydr Res 237 313 1992]. Itis FLAMMABLE and TOXIC.

Properties of N,O-Bis(trimethylsilyl)acetamide

Melting point: 24 °C
Boiling point: 71-73 °C35 mm Hg(lit.)
Density  0.832 g/mL at 20 °C(lit.)
vapor pressure  10 hPa (50 °C)
refractive index  n20/D 1.417(lit.)
Flash point: 53 °F
storage temp.  Store below +30°C.
solubility  Miscible with many nonpolar and polar aprotic solvents.
form  Crystalline Powder, Crystals and/or Chunks
pka 5.82±0.50(Predicted)
Specific Gravity 0.832
color  Light yellow or beige to brown
Hydrolytic Sensitivity 7: reacts slowly with moisture/water
Sensitive  Moisture Sensitive
BRN  1306669
CAS DataBase Reference 10416-59-8(CAS DataBase Reference)
NIST Chemistry Reference Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8)
EPA Substance Registry System Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester (10416-59-8)

Safety information for N,O-Bis(trimethylsilyl)acetamide

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
ghs
Corrosion
Corrosives
GHS05
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H226:Flammable liquids
H302:Acute toxicity,oral
H314:Skin corrosion/irritation
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for N,O-Bis(trimethylsilyl)acetamide

Related products of tetrahydrofuran

You may like

  • BIS (TRIMETHYL SILYL) ACETAMIDE 99%
    BIS (TRIMETHYL SILYL) ACETAMIDE 99%
    View Details
  • N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 mL × 8 / Reaction vial, capacity 2 mL × 8 [Trimethylsilylating Reagent, for NH2 compounds] CAS 10416-59-8
    N,O-Bis(trimethylsilyl)acetamide Kit TMS-BA (25% in Acetonitrile) 1 mL × 8 / Reaction vial, capacity 2 mL × 8 [Trimethylsilylating Reagent, for NH2 compounds] CAS 10416-59-8
    10416-59-8
    View Details
  • N,O-Bis(trimethylsilyl)acetamide CAS 10416-59-8
    N,O-Bis(trimethylsilyl)acetamide CAS 10416-59-8
    10416-59-8
    View Details
  • N,O-Bis(trimethylsilyl)acetamide CAS 10416-59-8
    N,O-Bis(trimethylsilyl)acetamide CAS 10416-59-8
    10416-59-8
    View Details
  • N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 mL × 8 / Reaction vial, capacity 2 mL × 8 CAS 10416-59-8
    N,O-Bis(trimethylsilyl)acetamide Kit BSA 1 mL × 8 / Reaction vial, capacity 2 mL × 8 CAS 10416-59-8
    10416-59-8
    View Details
  • N,O-Bis(trimethylsilyl)acetamide [Trimethylsilylating Agent] CAS 10416-59-8
    N,O-Bis(trimethylsilyl)acetamide [Trimethylsilylating Agent] CAS 10416-59-8
    10416-59-8
    View Details
  • N,O-Bis(trimethylsilyl)acetamide CAS 10416-59-8
    N,O-Bis(trimethylsilyl)acetamide CAS 10416-59-8
    10416-59-8
    View Details
  • N,O-BIS-(TRIMETHYLSILYL) ACETAMIDE 97% CAS 10416-59-8
    N,O-BIS-(TRIMETHYLSILYL) ACETAMIDE 97% CAS 10416-59-8
    10416-59-8
    View Details
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.