N-Octyl pyrrolidone

CAS NO.：2687-94-7
Empirical Formula: C12H23NO
Molecular Weight: 197.32
MDL number: MFCD00074965
EINECS: 403-700-8
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is N-Octyl pyrrolidone ?

Chemical properties

Colorless or slightly yellow clear liquid

The Uses of N-Octyl pyrrolidone

N-Octyl pyrrolidone(NOP) is a highly efficient and selective solvent, which can be used in the recovery of organic raw materials, the refining of lubricating oils, and the solvent for polymers and polymerization reactions; It is also widely used in chemical synthesis reactions.

Definition

ChEBI: N-Octyl-2-pyrrolidone is a N-alkylpyrrolidine.

Synthesis Reference(s)

The Journal of Organic Chemistry, 57, p. 3328, 1992 DOI: 10.1021/jo00038a019

Synthesis Reference(s)

The Journal of Organic Chemistry, 59, p. 6378, 1994 DOI: 10.1021/jo00100a046

General Description

1-Octyl-2-pyrrolidone is a permeation enhancer and its effect in transport of steroidal permeants across hairless mouse skin was investigated via a parallel pathway skin model.

Flammability and Explosibility

Non flammable

Safety Profile

Moderately toxic by ingestion. Asevere skin and eye irritant. A corrosive. Combustibleliquid. When heated to decomposition it emits toxic fumesof NOx.

Properties of N-Octyl pyrrolidone

Melting point:	−25 °C(lit.)
Boiling point:	170-172 °C15 mm Hg(lit.)
Density	0.92 g/mL at 25 °C(lit.)
vapor pressure	0.03-0.08Pa at 20℃
refractive index	n20/D 1.465(lit.)
Flash point:	>230 °F
storage temp.	Sealed in dry,Room Temperature
form	clear liquid
pka	-0.42±0.20(Predicted)
Specific Gravity	0.92
color	Colorless to Yellow
Water Solubility	1.14-1.25g/L at 20℃
BRN	1526318
CAS DataBase Reference	2687-94-7(CAS DataBase Reference)
EPA Substance Registry System	N-Octyl-2-pyrrolidone (2687-94-7)

Safety information for N-Octyl pyrrolidone

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Environment GHS09
GHS Hazard Statements	H314:Skin corrosion/irritation H411:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.