N-Methylolchloroacetamide

CAS NO.：2832-19-1
Empirical Formula: C3H6ClNO2
Molecular Weight: 123.54
MDL number: MFCD00021961
EINECS: 220-598-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-01 18:09:03

What is N-Methylolchloroacetamide ?

Chemical properties

White or almost white crystalline powder

The Uses of N-Methylolchloroacetamide

An organic building block. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals. As dyestuff intermediate .

The Uses of N-Methylolchloroacetamide

2-Chloro-N-(hydroxymethyl)acetamide (N-hydroxymethylchloroacetamide) may be used as a reagent in the synthesis of 1-(aminomethyl)-2-methoxynaphthalene hydrochloride and as a amidomethylating reagent for N,N-dialkylanilines (Tscherniac-Einhorn reaction).

The Uses of N-Methylolchloroacetamide

N-Methylolchloro-acetamide is a preservative in cooling fluids and cosmetics.

What are the applications of Application

An organic building block

General Description

2-Chloro-N-(hydroxymethyl)acetamide (N-methylolchloracetamide) is a N-hydroxymethyl derivative of chloroacetamide. One of the method reported for its synthesis is by the reaction of 2-chloracetamide with formaldehyde. It has been reported to be a formaldehyde releaser and an infrequent sensitizer to formaldehyde contact allergy. Influence of short and prolonged exposure of 2-chloro-N-(hydroxymethyl)acetamide (as formaldehyde donor/releaser) on lymph node responses has been investigated. It has high biocide action and is utilized as preservative.

Properties of N-Methylolchloroacetamide

Melting point:	100-105 °C(lit.)
Boiling point:	374.0±27.0 °C(Predicted)
Density	1.2776 (rough estimate)
refractive index	1.5000 (estimate)
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	12.63±0.46(Predicted)
color	White to Off-White
Water Solubility	Very soluble in water. Poorly soluble in aliphatic hydrocarbons.
Sensitive	Hygroscopic
BRN	1811765
CAS DataBase Reference	2832-19-1(CAS DataBase Reference)
EPA Substance Registry System	2-Chloro-N-(hydroxymethyl)acetamide (2832-19-1)

Safety information for N-Methylolchloroacetamide

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05
GHS Hazard Statements	H314:Skin corrosion/irritation
Precautionary Statement Codes	P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.