N-Methylolchloroacetamide
- CAS NO.:2832-19-1
- Empirical Formula: C3H6ClNO2
- Molecular Weight: 123.54
- MDL number: MFCD00021961
- EINECS: 220-598-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-24 19:19:26
What is N-Methylolchloroacetamide ?
Chemical properties
White or almost white crystalline powder
The Uses of N-Methylolchloroacetamide
N-Methylolchloro-acetamide is a preservative in cooling fluids and cosmetics.
The Uses of N-Methylolchloroacetamide
An organic building block. It is an important raw material and intermediate used in Organic Synthesis, Pharmaceuticals, Agrochemicals. As dyestuff intermediate .
The Uses of N-Methylolchloroacetamide
2-Chloro-N-(hydroxymethyl)acetamide (N-hydroxymethylchloroacetamide) may be used as a reagent in the synthesis of 1-(aminomethyl)-2-methoxynaphthalene hydrochloride and as a amidomethylating reagent for N,N-dialkylanilines (Tscherniac-Einhorn reaction).
What are the applications of Application
An organic building block
General Description
2-Chloro-N-(hydroxymethyl)acetamide (N-methylolchloracetamide) is a N-hydroxymethyl derivative of chloroacetamide. One of the method reported for its synthesis is by the reaction of 2-chloracetamide with formaldehyde. It has been reported to be a formaldehyde releaser and an infrequent sensitizer to formaldehyde contact allergy. Influence of short and prolonged exposure of 2-chloro-N-(hydroxymethyl)acetamide (as formaldehyde donor/releaser) on lymph node responses has been investigated. It has high biocide action and is utilized as preservative.
Properties of N-Methylolchloroacetamide
Melting point: | 100-105 °C(lit.) |
Boiling point: | 374.0±27.0 °C(Predicted) |
Density | 1.2776 (rough estimate) |
refractive index | 1.5000 (estimate) |
storage temp. | Inert atmosphere,2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 12.63±0.46(Predicted) |
color | White to Off-White |
Water Solubility | Very soluble in water. Poorly soluble in aliphatic hydrocarbons. |
Sensitive | Hygroscopic |
BRN | 1811765 |
CAS DataBase Reference | 2832-19-1(CAS DataBase Reference) |
EPA Substance Registry System | 2-Chloro-N-(hydroxymethyl)acetamide (2832-19-1) |
Safety information for N-Methylolchloroacetamide
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H314:Skin corrosion/irritation |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P363:Wash contaminated clothing before reuse. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-Methylolchloroacetamide
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