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HomeProduct name listN-desalkylflurazepam

N-desalkylflurazepam

Synonym(s):7-Chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;Desalkylflurazepam;Norfludiazepam

  • CAS NO.:2886-65-9
  • Empirical Formula: C15H10ClFN2O
  • Molecular Weight: 288.7
  • MDL number: MFCD00083443
  • EINECS: 220-748-3
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 08:55:08
N-desalkylflurazepam Structural

What is N-desalkylflurazepam?

Description

Desalkylflurazepam (Item No. 18484) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam , flutoprazepam, fludiazepam, midazolam, and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Cav; IC50s = 55 and 37 μM for Cav1.2 and 1.3, respectively) by positively modulating GABAA receptors. It can be detected in urine, serum, and meconium by LC-MS/MS. This product is intended for research and forensic applications.

Chemical properties

Light Yellow Solid

The Uses of N-desalkylflurazepam

The major human metabolite of flurazepam. This is a controlled drug precursor therefore a liscence may be required for purchase

Definition

ChEBI: Desalkylflurazepam is a benzodiazepine.

General Description

N-Desalkylflurazepam (also known as norflurazepam, 2886-65-9) is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

Mode of action

N-Desalkylflurazepam is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward.

Properties of N-desalkylflurazepam

Melting point: 204-206°C
Boiling point: 454.0±45.0 °C(Predicted)
Density  1.39±0.1 g/cm3(Predicted)
Flash point: 9℃
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), Methanol (Slightly)
pka 11.55±0.70(Predicted)
form  A neat solid
color  White to off-white
InChI InChI=1S/C15H10ClFN2O/c16-9-5-6-13-11(7-9)15(18-8-14(20)19-13)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,19,20)
CAS DataBase Reference 2886-65-9(CAS DataBase Reference)
NIST Chemistry Reference Norfludiazepam(2886-65-9)

Safety information for N-desalkylflurazepam

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H336:Specific target organ toxicity,single exposure; Narcotic effects
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P271:Use only outdoors or in a well-ventilated area.
P405:Store locked up.
P403+P233:Store in a well-ventilated place. Keep container tightly closed.
P501:Dispose of contents/container to..…

Computed Descriptors for N-desalkylflurazepam

InChIKey UVCOILFBWYKHHB-UHFFFAOYSA-N
SMILES N1C2=CC=C(Cl)C=C2C(C2=CC=CC=C2F)=NCC1=O

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