N-Chlorophthalimide

CAS NO.：3481-09-2
Empirical Formula: C8H4ClNO2
Molecular Weight: 181.58
MDL number: MFCD00023027
EINECS: 222-459-8
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-24 19:19:26

What is N-Chlorophthalimide?

Chemical properties

White to pale yellow powder

The Uses of N-Chlorophthalimide

N-Chlorophthalimide may be employed in the synthesis of:

α-amino acetal
α-amino nitro compounds
vicinal diamine
α,β-unsaturated vicinal haloamino nitro compound

It may also be used as a chlorination reagent for the synthesis of 3-(methylthio)oxindoles.

General Description

N-Chlorophthalimide in anhydrous acetic acid serves as a useful oxidizing reagent for use in various direct titrimetric analyses. N-Chlorophthalimide can be synthesized by reacting phthalimide, t-butyl hypochlorite, water and t-butyl alcohol. It participates in the synthesis of 2-amino-3-benzoyl-α-(methylthio)phenylacetamide.

Properties of N-Chlorophthalimide

Melting point:	188-198 °C (lit.)
Boiling point:	315.1±25.0 °C(Predicted)
Density	1.56±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
form	powder to crystal
pka	-3.53±0.20(Predicted)
color	White to Almost white
CAS DataBase Reference	3481-09-2(CAS DataBase Reference)

Safety information for N-Chlorophthalimide

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.