N-Boc-PEG4-bromide
- CAS NO.：1392499-32-9
- Empirical Formula: C15H30BrNO6
- Molecular Weight: 400.31
- MDL number: MFCD31536756
- Update Date: 2024-07-02 08:54:58
What is N-Boc-PEG4-bromide?
Description
N-Boc-PEG4-bromide is a PEG linker containing a bromide group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.
Biological Activity
N-Boc-PEG5-bromide is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
Properties of N-Boc-PEG4-bromide
| Boiling point: | 459.3±40.0 °C(Predicted) |
| Density | 1.223±0.06 g/cm3(Predicted) |
| solubility | Soluble in DCM |
| pka | 12.23±0.46(Predicted) |
| form | Liquid |
| color | Light yellow to brown |
Safety information for N-Boc-PEG4-bromide
Computed Descriptors for N-Boc-PEG4-bromide
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