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HomeProduct name listN-Boc-PEG4-bromide

N-Boc-PEG4-bromide

  • CAS NO.:1392499-32-9
  • Empirical Formula: C15H30BrNO6
  • Molecular Weight: 400.31
  • MDL number: MFCD31536756
  • Update Date: 2024-07-02 08:54:58
N-Boc-PEG4-bromide Structural

What is N-Boc-PEG4-bromide?

Description

N-Boc-PEG4-bromide is a PEG linker containing a bromide group and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Biological Activity

N-Boc-PEG5-bromide is a PROTAC linker that belongs to the PEG class and the Alkyl/ether class. It can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Properties of N-Boc-PEG4-bromide

Boiling point: 459.3±40.0 °C(Predicted)
Density  1.223±0.06 g/cm3(Predicted)
solubility  Soluble in DCM
pka 12.23±0.46(Predicted)
form  Liquid
color  Light yellow to brown

Safety information for N-Boc-PEG4-bromide

Computed Descriptors for N-Boc-PEG4-bromide

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