N-BOC-4-Hydroxypiperidine
Synonym(s):tert-Butyl 4-hydroxy-1-piperidinecarboxylate;1-Boc-4-piperidinol
- CAS NO.：109384-19-2
- Empirical Formula: C10H19NO3
- Molecular Weight: 201.26
- MDL number: MFCD01075174
- EINECS: 600-916-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-06-25 20:17:06
What is N-BOC-4-Hydroxypiperidine?
Chemical properties
White to cream powder
The Uses of N-BOC-4-Hydroxypiperidine
N-Boc-4-hydroxypiperidine is a 4-hydroxypyridine with a boc protecting group used in the preparation of neurologically active agents and other pharmaceutical compounds.
The Uses of N-BOC-4-Hydroxypiperidine
Used in a synthesis of N-heterocyclic alkyl ethers via the Mitsunobu reaction.
Preparation
A mixture of 4-hydroxypiperidine (10.0 g, 98. 9 mmol), aqueous sodiumhydrogen carbonate (150 mL, 1 M), DI-FERT-BUTYL dicarbonate (21. 6 g, 98.9 mmol) and dichloromethane was stirred for 15 h. The phases were separated and the product (N-BOC-4-Hydroxypiperidine) was isolated as an oil in quantitative yield (19.9 g).
Properties of N-BOC-4-Hydroxypiperidine
| Melting point: | 61-65 °C (lit.) |
| Boiling point: | 292.3±33.0 °C(Predicted) |
| Density | 1.107±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform, Ethyl Acetate |
| form | Powder |
| pka | 14.80±0.20(Predicted) |
| color | White to cream |
| BRN | 7202094 |
| InChI | InChI=1S/C10H19NO3/c1-10(2,3)14-9(13)11-6-4-8(12)5-7-11/h8,12H,4-7H2,1-3H3 |
| CAS DataBase Reference | 109384-19-2(CAS DataBase Reference) |
Safety information for N-BOC-4-Hydroxypiperidine
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for N-BOC-4-Hydroxypiperidine
| InChIKey | PWQLFIKTGRINFF-UHFFFAOYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCC(O)CC1 |
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