1-Boc-4-cyanopiperidine

Synonym(s):1,1-Dimethylethyl 4-cyano-1-piperidinecarboxylate;1-Boc-4-cyanopiperidine;4-Cyano-1-piperidinecarboxylic acid 1,1-dimethylethyl ester

CAS NO.：91419-52-2
Empirical Formula: C11H18N2O2
Molecular Weight: 210.27
MDL number: MFCD01861223
SAFETY DATA SHEET (SDS)
Update Date: 2025-01-27 09:38:02

What is 1-Boc-4-cyanopiperidine?

Chemical properties

Yellowish oil, soluble in Chloroform

The Uses of 1-Boc-4-cyanopiperidine

Reactant for synthesis of:

Aminomethylated fluoropiperidines
Protein kinase B inhibitors
GlyT1 inhibitors
Piperidinecarboxylic acids via nitrilase-catalyzed enantioselective synthesis

Reactant for

Replacement in CB2 receptor inhibitors
Double addition reactions of methyllithium and n-butyllithium to unsaturated nitriles

Synthesis

N-Boc-4- cyanopiperidine is an organic heterocyclic compound, which can be used as pharmaceutical intermediates. The synthesis of 1-Boc-4-cyanopiperidine is through the dehydration of oximes and amides to nitriles. The solution of the aldoxime and XtalFluor-E8 is mixed to extract with CH2Cl2 (2 × 10 mL), The combined organic layers were washed, dried, and concentrated under vacuum to afford the crude nitrile, which was purified by flash chromatography, if required.

Properties of 1-Boc-4-cyanopiperidine

Melting point:	60-63 °C
Boiling point:	325.3±35.0 °C(Predicted)
Density	1.07±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Chloroform
pka	-3.08±0.40(Predicted)
form	Crystalline Powder
color	White to off-white
InChI	InChI=1S/C11H18N2O2/c1-11(2,3)15-10(14)13-6-4-9(8-12)5-7-13/h9H,4-7H2,1-3H3
CAS DataBase Reference	91419-52-2(CAS DataBase Reference)

Safety information for 1-Boc-4-cyanopiperidine

Signal word	Warning
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Exclamation Mark Irritant GHS07 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H312:Acute toxicity,dermal H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…