N-Boc-4-piperidinemethanol
Synonym(s):N-tert-Butyloxycarbonyl-4-piperidinemethanol
- CAS NO.:123855-51-6
- Empirical Formula: C11H21NO3
- Molecular Weight: 215.29
- MDL number: MFCD02094488
- EINECS: 628-428-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 14:09:54
What is N-Boc-4-piperidinemethanol?
Chemical properties
White to light brown solid
The Uses of N-Boc-4-piperidinemethanol
N-Boc-4-piperidinemethanol is an important piperidine derivative, which can be used in organic synthesis and pharmaceutical intermediates, It may be used to synthesize:
methyl 5-methoxy-4-(1-methylpiperidin-4-ylmethoxy)-2-nitrobenzoate
N-Boc-4-piperidinecarboxaldehyde
[1-(tert-butoxycarbonyl)piperidin-4-yl]methyl methanesulfonate
Involved in the synthesis of bradycardic agents.
What are the applications of Application
N-Boc-4-piperidinemethanol is useful for the synthesis of bradycardic agents
What are the applications of Application
N-Boc-4-piperidinemethanol is a curcumin analogue that binds to the epidermal growth factor receptor (EGFR) and prevents the binding of ligands. In vitro studies have shown that it can inhibit tumor growth and induce apoptosis in cancer cells. The drug is also capable of inhibiting the proliferation of normal cells, which may be due to its ability to recruit EGFR from outside the cell membrane. This process triggers signaling events that lead to cell death.
General Description
N-Boc-4-piperidinemethanol contains a tert-butyloxycarbonyl (t-BOC)-protecting group. It can be synthesized from 4-piperidinemethanol via reaction with di-tert-butyldicarbonate.
Properties of N-Boc-4-piperidinemethanol
Melting point: | 78-82 °C (lit.) |
Boiling point: | 308.0±15.0 °C(Predicted) |
Density | 1.059±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | soluble in Methanol |
form | Powder |
pka | 14.94±0.10(Predicted) |
color | White to brown |
InChI | InChI=1S/C11H21NO3/c1-11(2,3)15-10(14)12-6-4-9(8-13)5-7-12/h9,13H,4-8H2,1-3H3 |
CAS DataBase Reference | 123855-51-6(CAS DataBase Reference) |
Safety information for N-Boc-4-piperidinemethanol
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for N-Boc-4-piperidinemethanol
InChIKey | CTEDVGRUGMPBHE-UHFFFAOYSA-N |
SMILES | N1(C(OC(C)(C)C)=O)CCC(CO)CC1 |
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