1-Boc-3-piperidone
Synonym(s):tert-Butyl 3-oxopiperidine-1-carboxylate
- CAS NO.:98977-36-7
- Empirical Formula: C10H17NO3
- Molecular Weight: 199.25
- MDL number: MFCD01631193
- EINECS: 629-575-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-06 16:32:36
What is 1-Boc-3-piperidone?
Chemical properties
White to yellow low melting solid
The Uses of 1-Boc-3-piperidone
1-Boc-3-piperidone, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthesis
With 179g compound 3(1-BOC-3-piperidines alcohol) drop in the 2L reaction flask, drop into pimelinketone 1300g, aluminum isopropylate 88g, methylene dichloride 400ml is warming up to 80 ℃, insulation reaction 8h, reaction finishes to be cooled to room temperature, adds 10% sodium hydroxide 200ml, stirring at normal temperature 30min, filter, the filtrate normal pressure reclaims methylene dichloride, reclaim under reduced pressure pimelinketone again, reclaim finish after, add the 300ml dichloromethane extraction three times, it is dry concentrated to merge oil reservoir, gets 1-BOC-3-piperidone crude product.
Refining: with 1-BOC-3-piperidone crude product is that 60pa, temperature are to distill under 104 ~ 105 ℃ the condition at pressure, gets 1-BOC-3-piperidone elaboration 163g, 92.9%.
Properties of 1-Boc-3-piperidone
Melting point: | 35-40 °C (lit.) |
Boiling point: | 289.8±33.0 °C(Predicted) |
Density | 1.099±0.06 g/cm3(Predicted) |
Flash point: | >230 °F |
storage temp. | 2-8°C |
form | Liquid |
pka | -1.71±0.20(Predicted) |
color | Clear colorless |
Water Solubility | It is insoluble in water. |
BRN | 5936353 |
CAS DataBase Reference | 98977-36-7(CAS DataBase Reference) |
Safety information for 1-Boc-3-piperidone
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 1-Boc-3-piperidone
Abamectin manufacturer
TAGOOR LABORATORIES PVT LTD
REDDY N REDDY PHARMACEUTICALS
JSK Chemicals
ALS INDIA LIFE SCIENCES
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