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HomeProduct name list1-Boc-3-piperidone

1-Boc-3-piperidone

Synonym(s):tert-Butyl 3-oxopiperidine-1-carboxylate

  • CAS NO.:98977-36-7
  • Empirical Formula: C10H17NO3
  • Molecular Weight: 199.25
  • MDL number: MFCD01631193
  • EINECS: 629-575-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-08-06 16:32:36
1-Boc-3-piperidone Structural

What is 1-Boc-3-piperidone?

Chemical properties

White to yellow low melting solid

The Uses of 1-Boc-3-piperidone

1-Boc-3-piperidone, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

Synthesis

With 179g compound 3(1-BOC-3-piperidines alcohol) drop in the 2L reaction flask, drop into pimelinketone 1300g, aluminum isopropylate 88g, methylene dichloride 400ml is warming up to 80 ℃, insulation reaction 8h, reaction finishes to be cooled to room temperature, adds 10% sodium hydroxide 200ml, stirring at normal temperature 30min, filter, the filtrate normal pressure reclaims methylene dichloride, reclaim under reduced pressure pimelinketone again, reclaim finish after, add the 300ml dichloromethane extraction three times, it is dry concentrated to merge oil reservoir, gets 1-BOC-3-piperidone crude product.
Refining: with 1-BOC-3-piperidone crude product is that 60pa, temperature are to distill under 104 ~ 105 ℃ the condition at pressure, gets 1-BOC-3-piperidone elaboration 163g, 92.9%.

Properties of 1-Boc-3-piperidone

Melting point: 35-40 °C (lit.)
Boiling point: 289.8±33.0 °C(Predicted)
Density  1.099±0.06 g/cm3(Predicted)
Flash point: >230 °F
storage temp.  2-8°C
form  Liquid
pka -1.71±0.20(Predicted)
color  Clear colorless
Water Solubility  It is insoluble in water.
BRN  5936353
CAS DataBase Reference 98977-36-7(CAS DataBase Reference)

Safety information for 1-Boc-3-piperidone

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 1-Boc-3-piperidone

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