N-Boc-3-pyrrolidinone

Synonym(s):N-(tert-Butoxycarbonyl)-3-pyrrolidinone

CAS NO.：101385-93-7
Empirical Formula: C9H15NO3
Molecular Weight: 185.22
MDL number: MFCD01631194
EINECS: 600-204-5
SAFETY DATA SHEET (SDS)
Update Date: 2024-05-14 16:41:43

What is N-Boc-3-pyrrolidinone?

Description

N-Boc-3-pyrrolidinone is an organic compound insoluble in water. It is a starting material for the synthesis of spirocyclic tetrahydrofuran and is also used in studies related to the preparation of 5-membered heterocyclic secondary alcohols with carrot as a biocatalyst^[1].

Chemical properties

Brown Oil

The Uses of N-Boc-3-pyrrolidinone

In the Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins 1-Boc-3-pyrrolidinone is used.

The Uses of N-Boc-3-pyrrolidinone

Used in a study of asymmetric hydrogen-transfer bioreduction of ketones with Leifsonia alcohol dehydrogenase.

References

[1] NAIRA VIEIRA MACHADO á. O. Enantioselective reduction of heterocyclic ketones with low level of asymmetry using carrots[J]. Biocatalysis and Biotransformation, 2021. DOI:10.1080/10242422.2021.1879795.

Properties of N-Boc-3-pyrrolidinone

Melting point:	34-38 °C (lit.)
Boiling point:	270.9±33.0 °C(Predicted)
Density	1.133±0.06 g/cm3(Predicted)
Flash point:	>230 °F
storage temp.	2-8°C
solubility	Dichloromethane, Ethyl Acetate, Methanol
form	Low Melting Solid
pka	-1.79±0.20(Predicted)
color	White to yellow to orange
Water Solubility	Insoluble in water.
CAS DataBase Reference	101385-93-7(CAS DataBase Reference)

Safety information for N-Boc-3-pyrrolidinone

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.