MMP-2/MMP-9 INHIBITOR IV
Synonym(s):2-[[(4-phenoxyphenyl)sulfonyl]methyl]-Thiirane;MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem;SB-3CT
- CAS NO.:292605-14-2
- Empirical Formula: C15H14O3S2
- Molecular Weight: 306.4
- MDL number: MFCD09836266
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 16:48:35
What is MMP-2/MMP-9 INHIBITOR IV?
The Uses of MMP-2/MMP-9 INHIBITOR IV
SB 3CT is a selective and potent gelatinase inhibitor which may be used for the treatment of brain metastasis.
The Uses of MMP-2/MMP-9 INHIBITOR IV
SB?3CT has been used as irreversible inhibitor of matrix metallopeptidase 9 (MMP9) in cell cultures to exclude reciprocal regulation.
What are the applications of Application
SB-3CT is an inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9)
Definition
ChEBI: 2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane is an aromatic ether.
Biochem/physiol Actions
SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. In particular, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. SB-3CT exhibits a covalent mechanism based behavior in inhibition of MMP-2 and MMP-9. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. SB-3CT has been shown to directly bind to the zinc in the catalytic site of MMP-2. SB-3CT does not affect the activities of MMP-1 (Ki = 206 μM) MMP-3 (Ki = 15 μM), or MMP-7 (Ki = 96 μM).
storage
Store at -20°C
Properties of MMP-2/MMP-9 INHIBITOR IV
Melting point: | 92-96°C |
Boiling point: | 501.4±46.0 °C(Predicted) |
Density | 1.329±0.06 g/cm3(Predicted) |
storage temp. | -20°C |
solubility | DMSO: >20mg/mL |
form | powder |
color | white to off-white |
Safety information for MMP-2/MMP-9 INHIBITOR IV
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for MMP-2/MMP-9 INHIBITOR IV
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