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HomeProduct name listMMP-2/MMP-9 INHIBITOR IV

MMP-2/MMP-9 INHIBITOR IV

Synonym(s):2-[[(4-phenoxyphenyl)sulfonyl]methyl]-Thiirane;MMP-2/MMP-9 Inhibitor IV - CAS 292605-14-2 - Calbiochem;SB-3CT

MMP-2/MMP-9 INHIBITOR IV Structural

What is MMP-2/MMP-9 INHIBITOR IV?

The Uses of MMP-2/MMP-9 INHIBITOR IV

SB 3CT is a selective and potent gelatinase inhibitor which may be used for the treatment of brain metastasis.

The Uses of MMP-2/MMP-9 INHIBITOR IV

SB?3CT has been used as irreversible inhibitor of matrix metallopeptidase 9 (MMP9) in cell cultures to exclude reciprocal regulation.

What are the applications of Application

SB-3CT is an inhibitor of matrix metalloproteinases 2 and 9 (MMP-2 and MMP-9)

Definition

ChEBI: 2-[(4-phenoxyphenyl)sulfonylmethyl]thiirane is an aromatic ether.

Biochem/physiol Actions

SB-3CT is a potent matrix metalloproteinase MMP-2 and MMP-9 inhibitor. Matrix metalloproteinases (MMPs) are involved in a number of activities including angiogenesis and embryogenesis. In particular, gelatinases A (MMP-2) and B (MMP-9), are thought to facilitate tumor metastasis. SB-3CT exhibits a covalent mechanism based behavior in inhibition of MMP-2 and MMP-9. This inhibitor appears to have similarity to TIMP-1 and TIMP-2 in the slow-binding component of inhibition. SB-3CT has been shown to directly bind to the zinc in the catalytic site of MMP-2. SB-3CT does not affect the activities of MMP-1 (Ki = 206 μM) MMP-3 (Ki = 15 μM), or MMP-7 (Ki = 96 μM).

storage

Store at -20°C

Properties of MMP-2/MMP-9 INHIBITOR IV

Melting point: 92-96°C
Boiling point: 501.4±46.0 °C(Predicted)
Density  1.329±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  DMSO: >20mg/mL
form  powder
color  white to off-white

Safety information for MMP-2/MMP-9 INHIBITOR IV

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for MMP-2/MMP-9 INHIBITOR IV

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