MM-102
- CAS NO.:1417329-24-8
- Empirical Formula: C35H49F2N7O4
- Molecular Weight: 669.8
- MDL number: MFCD28015099
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-31 21:04:56
What is MM-102?
The Uses of MM-102
MM-102 is a small molecule WDR5/MLL1 protein-protein interaction inhibitor. MM-102 in bone marrow cells transduced with MLL1-AF9 fusion construct decreases the expression of HoxA9 and Meis-1, two critical MLL1 target genes in MLL1 fusion protein mediated leukemogenesis.
Biological Activity
mm-102 is an antagonist of mll1 with ic50 value of 2.4nm [1].mixed lineage leukemia 1 (mll1) is a histone h3 lysine 4 (h3k4) methyltransferase. the interaction of mll1 and wdr5 is essential for mll1 enzymatic activity and is a target for the treatment of acute leukemia. mm-102 is a peptidomimetic of mll1. it has a high binding affinity to wdr5 with ic50 value of 2.4nm [1].mm-102 is reported to reduce the expression of mll1 targeted genes hoxa9 and meis-1 in mll1-af9 transduced murine cells. since these two genes are required for mll1 mediated leukemogenesis, mm-102 is found to inhibit cell growth of leukemia cells harboring mll1 fusion proteins. it dose-dependently inhibits the cell growth in the mv4;11 and kopn8 cell lines with ic50 values both of 25μm[1].
References
[1] karatas h, townsend ec, cao f, chen y, bernard d, liu l, lei m, dou y, wang s. high-affinity, small-molecule peptidomimetic inhibitors of mll1/wdr5 protein-protein interaction. j am chem soc. 2013 jan 16;135(2):669-82.
Properties of MM-102
Density | 1.26±0.1 g/cm3(Predicted) |
storage temp. | Store at -20° C |
solubility | insoluble in H2O; ≥22.6 mg/mL in EtOH; ≥67 mg/mL in DMSO |
form | Powder |
pka | 12.90±0.20(Predicted) |
color | White to off-white |
Safety information for MM-102
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for MM-102
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