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HomeProduct name list2-(4-Isopropylpheny)-4H-chroMen-4-one

2-(4-Isopropylpheny)-4H-chroMen-4-one

Synonym(s):2-[4-(1-Methylethyl)phenyl]-4H-1-benzopyran-4-one

2-(4-Isopropylpheny)-4H-chroMen-4-one Structural

What is 2-(4-Isopropylpheny)-4H-chroMen-4-one?

The Uses of 2-(4-Isopropylpheny)-4H-chroMen-4-one

2-[4-(1-Methylethyl)phenyl4H-1-benzopyran-4-one is a potent and selective tankyrase (TNKS) inhibitor affecting cell proliferation with potential treatment for cancers. Flavonoid compound with anti-cancer/ anti-bacterial properties.

Biological Activity

mn-64 is a type of flavone that act as a potent and selective tankyrase inhibitor (ic50 = 6 and 72 nm for tnks1 and tnks2, respectively). [1]tankytase (tnks) is a member of poly adp ribose polymerases (parps). there are two related homologue, tnks1 and tnks2 that are mostly located in the nuclear pore, cytoplasm, mitotic centrosomes and the golgi apparatus. they involve in cellular functions such as regulation of cell proliferation and promoting telomere elongation in human cells. [1]during an assay for screening flavone tnks inhibitors, mn-64 is discovered for abrogating stf luciferase activity at 200nm and potently inhibiting tnks1 with ic50 of 6nm. it also selectively inhibits tnks1 and tnks2 without affecting any other parps. moreover, mn-64 is prominently more selective than other tnks inhibitors such as xav939. [1]

Biochem/physiol Actions

MN-64 is a very potent inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively). The compound MN-64 blocks Wnt signaling in HEK293 cells containing a Wnt pathway reporter system.

References

1. narwal m, koivunen j, haikarainen t et al. discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. j med chem. 2013 oct 24;56(20):7880-9.

Properties of 2-(4-Isopropylpheny)-4H-chroMen-4-one

Melting point: 63-64 °C(Solv: ethanol (64-17-5))
Boiling point: 389.8±42.0 °C(Predicted)
Density  1.152±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO: soluble20mg/mL, clear
form  powder
color  white to beige

Safety information for 2-(4-Isopropylpheny)-4H-chroMen-4-one

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for 2-(4-Isopropylpheny)-4H-chroMen-4-one

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