BIX 01294
Synonym(s):2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine trihydrochloride hydrate;BIX 01294
- CAS NO.:1392399-03-9
- Empirical Formula: C28H41Cl3N6O2
- Molecular Weight: 600.02314
- MDL number: MFCD16618384
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-09-20 16:43:00
![BIX 01294 Structural](https://img.chemicalbook.in/CAS/20180713/GIF/1392399-03-9.gif)
What is BIX 01294?
The Uses of BIX 01294
BIX 01294 trihydrochloride hydrate has been used:
- as a histone methylation inhibitor to treat E4 cells for analysing green fluorescent protein (d2EGFP) expression
- to investigate the role of G9a in neuroblastoma tumor growth
- as specific inhibitor of G9a to treat the SK-N-AS, BE(2)-C, SK-N-DZ, SK-N-F1, and SHEP1 neuroblastoma cell lines
What are the applications of Application
BIX01294 hydrochloride is a selective histone methyl transferase (HMTase) inhibitor.
General Description
BIX-01294, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. BIX-01294 inhibits the G9aHMTase dependent levels of histone-3 lysine (9) methylation (H3K9me). Bix-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.
Biochem/physiol Actions
BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro.
storage
room temperature (desiccate)
Properties of BIX 01294
storage temp. | Inert atmosphere,2-8°C |
solubility | H2O: >20mg/mL |
form | powder |
color | white |
Safety information for BIX 01294
Signal word | Warning |
Pictogram(s) |
![]() Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for BIX 01294
New Products
3-Pyridineacrylic acid 3-Bromo-4-fluorophenol N-Boc-Ethylenediamine cis-[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl-4-methylbenzenesulphonate 4-Aminotetrahydropyran hydrochloride 4,5-Dibromopyridazin-3-one N-Benzyl-3-hydroxypiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,4-Dichloro-5-Methylpyridine 2-Amino-6-Chloro-3-Nitropyridine 2-Chloro-4-Nitropyridine-N-Oxide 3-Amino-5-Chloropyridine 2-Fluoroisonicotinic acid 2-Hydroxy-5-Methylpyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-AminophenaethylalcholRelated products of tetrahydrofuran
![](https://img.chemicalbook.in/CAS/GIF/1357302-64-7.gif)
![](https://img.chemicalbook.in/CAS/20180808/GIF/1417329-24-8.gif)
![](https://img.chemicalbook.in/CAS/20150408/GIF/1380288-87-8.gif)
![](https://img.chemicalbook.in/CAS/20150408/GIF/1346704-33-3.gif)
![](https://img.chemicalbook.in/CAS/20150408/GIF/1373423-53-0.gif)
![](https://img.chemicalbook.in/CAS/20150408/GIF/1403254-99-8.gif)
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