UK-371804 hydrochloride

Synonym(s):2-(((4-Chloro-1-guanidino-7-isoquinolinyl)sulfonyl)amino)-isobutyric acid hydrochloride;N-[[1-[(aminoiminomethyl)amino]-4-chloro-7-isoquinolinyl]sulfonyl]-2-methyl-alanine hydrochloride;UK-371804 HCl

CAS NO.：256476-36-5
Empirical Formula: C14H17Cl2N5O4S
Molecular Weight: 422.28
MDL number: MFCD31558512
Update Date: 2024-10-28 23:16:16

What is UK-371804 hydrochloride?

Biochem/physiol Actions

UK-371,804 is a reversible, substrate-competitive, highly potent (Ki = 10 nM) and selective urokinase-type plasminogen activator (uPA) Inhibitor with excellent selectivity over tPA, plasmin, Factor IXa and Xa. When applied topically, UK-371,80 effectively penetrates into excisional wounds of experimental pigs with no adverse effect on wound closure. UK-371,804 effectively blocks EGR-FMK from binding human uPA even in the presence of tissue proteins.

Properties of UK-371804 hydrochloride

Melting point:	258 °C (decomp)
storage temp.	-20°C
solubility	DMSO: 42 mg/mL (99.46 mM);Ethanol: Insoluble
form	powder
color	white to beige
Water Solubility	Water: Insoluble

Safety information for UK-371804 hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.