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HomeProduct name listMKC3946

MKC3946

  • CAS NO.:1093119-54-0
  • Empirical Formula: C21H20N2O3S
  • Molecular Weight: 380.46
  • Update Date: 2024-11-19 23:02:33
MKC3946 Structural

What is MKC3946?

Biological Activity

MKC3946 is a soluble inhibitor of the IRE1α endoribonuclease domain, causing moderate growth inhibition in multiple myeloma cell lines without toxic effects on normal monocytes.

in vivo

In an in vivo model of endoplasmic reticulum stress, MKC-3946 inhibits cleavage of XBP1 and significantly inhibits myeloma cell growth.

Properties of MKC3946

Boiling point: 591.6±50.0 °C(Predicted)
Density  1.337±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  DMSO:20.0(Max Conc. mg/mL);52.57(Max Conc. mM)
form  A crystalline solid
pka 8.18±0.50(Predicted)
color  White to yellow

Safety information for MKC3946

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for MKC3946

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