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HomeProduct name listMitiglinide calcium dihydrate

Mitiglinide calcium dihydrate

  • CAS NO.:207844-01-7
  • Empirical Formula: C38H52CaN2O8
  • Molecular Weight: 704.91
  • MDL number: MFCD08460119
  • EINECS: 1308068-626-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
Mitiglinide calcium dihydrate Structural

What is Mitiglinide calcium dihydrate?

Description

Mitiglinide calcium hydrate (KAD-1229) is an insulinotropic agent. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels.

Chemical properties

White Solid

The Uses of Mitiglinide calcium dihydrate

KAD-1229 binds to sulfonylurea receptors and inhibits the activity of ATP-sensitive K+ channel in MIN 6 cells. Antidiabetic.

Mechanism of action

Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells, and its early insulin release and short duration of action would be effective in improving postprandial hyperglycemia.

Properties of Mitiglinide calcium dihydrate

Melting point: 179-185°C
storage temp.  Inert atmosphere,Room Temperature
solubility  Methanol (Slightly)
form  Solid
color  White
CAS DataBase Reference 207844-01-7(CAS DataBase Reference)

Safety information for Mitiglinide calcium dihydrate

Computed Descriptors for Mitiglinide calcium dihydrate

InChIKey QEVLNUAVAONTEW-HNIWBTCONA-L
SMILES N1(C[C@]2([H])CCCC[C@]2([H])C1)C(=O)C[C@H](CC1=CC=CC=C1)C(=O)O[Ca]OC(=O)[C@@H](CC1=CC=CC=C1)CC(=O)N1C[C@@]2([H])CCCC[C@@]2([H])C1.O.O |&1:2,8,14,29,42,48,r|

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