Mitiglinide calcium dihydrate
- CAS NO.：207844-01-7
- Empirical Formula: C38H52CaN2O8
- Molecular Weight: 704.91
- MDL number: MFCD08460119
- EINECS: 1308068-626-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 15:53:33
What is Mitiglinide calcium dihydrate?
Description
Mitiglinide calcium hydrate (KAD-1229) is an insulinotropic agent. Mitiglinide calcium hydrate is highly specific to the Kir6.2/SUR1 complex (the pancreatic beta-cell KATP channel). Mitiglinide is a drug for the treatment of type 2 diabetes. It may stimulate insulin secretion in beta-cells by closing off ATP dependant potassium ion channels.
Chemical properties
White Solid
The Uses of Mitiglinide calcium dihydrate
KAD-1229 binds to sulfonylurea receptors and inhibits the activity of ATP-sensitive K+ channel in MIN 6 cells. Antidiabetic.
Mechanism of action
Mitiglinide is thought to stimulate insulin secretion by closing the ATP-sensitive K(+) (K(ATP)) channels in pancreatic beta-cells, and its early insulin release and short duration of action would be effective in improving postprandial hyperglycemia.
Properties of Mitiglinide calcium dihydrate
| Melting point: | 179-185°C |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Methanol (Slightly) |
| form | Solid |
| color | White |
| CAS DataBase Reference | 207844-01-7(CAS DataBase Reference) |
Safety information for Mitiglinide calcium dihydrate
Computed Descriptors for Mitiglinide calcium dihydrate
| InChIKey | QEVLNUAVAONTEW-HNIWBTCONA-L |
| SMILES | N1(C[C@]2([H])CCCC[C@]2([H])C1)C(=O)C[C@H](CC1=CC=CC=C1)C(=O)O[Ca]OC(=O)[C@@H](CC1=CC=CC=C1)CC(=O)N1C[C@@]2([H])CCCC[C@@]2([H])C1.O.O |&1:2,8,14,29,42,48,r| |
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