Benzyl benzoate
Synonym(s):Benzoic acid benzyl ester;Benzyl benzoate;Benzylis benzoas
- CAS NO.:120-51-4
- Empirical Formula: C14H12O2
- Molecular Weight: 212.24
- MDL number: MFCD00003075
- EINECS: 204-402-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-14 11:56:19
What is Benzyl benzoate?
Absorption
No data are available on percutaneous absorption of benzyl benzoate. Some older studies have suggested some percutaneous absorption, however the amount was not quantified.
Toxicity
Oral, rabbit: LD50 = 1680 mg/kg; Skin, rabbit: LD50 = 4000 mg/kg. Symptoms of overdose include blister formation, crusting, itching, oozing, reddening, or scaling of skin; difficulty in urinating (dribbling); jerking movements; sudden loss of consciousness.
Description
Benzyl benzoate is the ester of benzyl alcohol and benzoic acid, with the formula C6H5CH2O2CC6H5. This easily prepared compound with a mild balsamic odor has a variety of uses.Benzyl benzoate (BB) is one of the oldest drugs used for the treatment of scabies and is recommended as the “first-line intervention” for the cost-effective treatment of the disease.
The Uses of Benzyl benzoate
benzyl benzoate is an anti-microbial. It can also act as a solvent, helping dissolve other substances in the product, and as a perfuming ingredient. It is the ester of benzyl alcohol and benzoic acid.
Indications
Used to kill lice and the mites responsible for the skin condition scabies.
Background
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.
What are the applications of Application
Benzyl benzoate is an antiparasitic, insecticidal agent
Pharmacokinetics
Benzyl benzoate is one of the older preparations used to treat scabies. Scabies is a skin infection caused by the mite sarcoptes scabiei. It is characterised by severe itching (particularly at night), red spots, and may lead to a secondary infection. Benzyl benzoate is lethal to this mite and so is useful in the treatment of scabies. It is also used to treat lice infestation of the head and body. Benzyl benzoate is not the treatment of choice for scabies due to its irritant properties.
Metabolism
Rapidly hydrolyzed to benzoic acid and benzyl alcohol, which is further oxidized to benzoic acid. The benzoic acid is conjugated with glycine to form hippuric acid.
Properties of Benzyl benzoate
Melting point: | 17-20 °C (lit.) |
Boiling point: | 323-324 °C (lit.) |
Density | 1.118 g/mL at 20 °C (lit.) |
Flash point: | 298 °F |
storage temp. | 2-8°C |
solubility | Miscible with ethanol, alcohol, chloroform, ether, oils. |
form | Liquid |
color | Clear colorless |
Water Solubility | practically insoluble |
Safety information for Benzyl benzoate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H302:Acute toxicity,oral H411:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P273:Avoid release to the environment. P391:Collect spillage. Hazardous to the aquatic environment P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Benzyl benzoate
InChIKey | SESFRYSPDFLNCH-UHFFFAOYSA-N |
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