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HomeProduct name listMidazolam hydrochloride

Midazolam hydrochloride

Synonym(s):8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5a][1,4]benzodiazepine hydrochloride

  • CAS NO.:59467-96-8
  • Empirical Formula: C18H14Cl2FN3
  • Molecular Weight: 362.23
  • MDL number: MFCD01721980
  • EINECS: 261-776-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-30 15:45:59
Midazolam hydrochloride Structural

What is Midazolam hydrochloride?

The Uses of Midazolam hydrochloride

Midazolam Hydrochloride is a sensitive CYP 3A4 probe substrate.

The Uses of Midazolam hydrochloride

Anti-Spasmodic

Definition

ChEBI: Midazolam hydrochloride is the hydrochloride salt of midazolam. It has a role as an anticonvulsant, an antineoplastic agent, an anxiolytic drug, an apoptosis inducer, a central nervous system depressant, a GABAA receptor agonist, a general anaesthetic, a muscle relaxant and a sedative. It is an imidazobenzodiazepine and a hydrochloride. It contains a midazolam.

brand name

Versed (Roche).

Biological Activity

Sedative/hypnotic agent that acts at the GABA A receptor benzodiazepine modulatory site.

Veterinary Drugs and Treatments

In veterinary patients, midazolam is used principally as a premedicant for general anesthesia. Alone, it does not appear to provide predictable sedation in animals. Animals may become sedated or dysphoric and excited. Cats may be more prone to develop the “excited” effect more than dogs. When used in combination with other drugs (i.e., opioids or ketamine), midazolam does provide more predictable sedation.
Midazolam may also be of benefit to treat status epilepticus when given either IV or IM (not rectally).
In humans, midazolam has been suggested for use as a premedicant before surgery, and as a conscious sedative when combined with potent analgesic/anesthetic drugs (e.g., ketamine or fentanyl). In humans, midazolam reduces the incidences of “dreamlike” emergence reactions and increases in blood pressure and cardiac rate caused by ketamine.
When compared to the thiobarbiturate induction agents (e.g., thiamylal, thiopental), midazolam has less cardiopulmonary depressant effects, is water-soluble, can be mixed with several other agents, and does not tend to accumulate in the body after repeated doses.

storage

Desiccate at RT

Properties of Midazolam hydrochloride

storage temp.  2-8°C
Water Solubility  Soluble to 25 mM in water
EPA Substance Registry System Midazolam hydrochloride (59467-96-8)

Safety information for Midazolam hydrochloride

Computed Descriptors for Midazolam hydrochloride

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