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HomeProduct name listMETHYLERGONOVINE

METHYLERGONOVINE

  • CAS NO.:113-42-8
  • Empirical Formula: C20H25N3O2
  • Molecular Weight: 339.44
  • MDL number: MFCD00242879
  • EINECS: 204-027-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:31
METHYLERGONOVINE Structural

What is METHYLERGONOVINE?

Absorption

Absorption is rapid after oral (60% bioavailability) and intramuscular (78% bioavailability) administration.

Toxicity

Signs and symptoms of overexposure: hypertension, seizures, headache, hypotension, nausea, and vomiting.

Chemical properties

Shiny crystals; melts at 172°C (341.6°F);moderately soluble in water, dissolves readilyin alcohol and acetone.

Originator

Methergine,Sandoz,US,1948

The Uses of METHYLERGONOVINE

Methylergonovine is a drug currently used as a smooth muscle constrictor during postpartum hemorrhage, as an inhibitor of the inflammasome complex in ASC-mediated procaspase-1 activation screening.

The Uses of METHYLERGONOVINE

Oxytocic.

The Uses of METHYLERGONOVINE

This compound is a homologue of ergonovine.It is used in the treatment of postpartumhemorrhage.

Background

A homolog of ergonovine containing one more CH2 group. (Merck Index, 11th ed)

Indications

For the prevention and control of excessive bleeding following vaginal childbirth

Definition

ChEBI: (6aR,9R)-N-[(2S)-1-hydroxybutan-2-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide is an ergoline alkaloid.

Manufacturing Process

To a freshly prepared solution of 2 parts of d-isolysergic acid azide in 300 parts of either is added an ethereal solution of 2 parts of d-2-aminobutanol-1 and the mixture is left to stand at room temperature during 12 hours. The yellowish clear solution is then washed several times with some water, dried over sodium sulfate and the ether evaporated in vacuo. The crystallized residue is treated with a small quantity of acetone and filtered. Yield: 2.2 parts of d-isolysergic acid-d-1-hydroxybutylamide-2. On recrystallization from some hot methanol the new compound is obtained in form of beautiful polygonal crystals that melt with some decomposition at 192° to 194°C (corr.).
1 part of the iso-compound is then dissolved in 10 parts of absolute ethanol and an alcoholic potassium hydroxide solution is added thereto. The mixture is left to stand at room temperature during 45 minutes. After this time equilibrium is reached between lysergic acid and the isolysergic acid forms, which can be checked by determination of the constancy of the optical rotation of the solution. When this point is reached, potassium hydroxide is transformed into potassium carbonate by bubbling through the solution a stream of carbon dioxide; the thick crystal paste of potassium carbonate is then diluted with 50 parts of ether, filtered and washed again with 50 parts of ether.
The alcoholic ethereal filtrate is then dried over calcined potassium carbonate and the solution evaporated, whereby 0.9 to 1 part of a mixture of d-lysergic acid-d-1-hydroxybutylamide-2 and of d-isolysergic acid-d-1- hydroxybutylamide-2 is obtained. In order to separate the isomers, the residue is dissolved in 15 parts of hot chloroform and filtered from the small quantity of inorganic salt, whereby on cooling down, the difficultly soluble chloroform compound of d-lysergic acid-d-1-hydroxybutylamide-2 crystallizes out. Yield: 0.4 part. This compound can be recrystallized from hot benzene, whereby crystals melting with some decomposition at 172°C (corr.) are obtained. It may then be reacted with maleic acid to give the maleate.

brand name

Methergine(Novartis).

Therapeutic Function

Oxytocic

Health Hazard

The toxic effects due to methylergonovine inhumans include nausea, vomiting, dizziness,and hypertension. The oral and intravenousLD50 values in mice are 187 and 85 mg/kg,respectively.

Biological Activity

Active metabolite of methysergide ; uterotonic agent and oxytocic.

Pharmacokinetics

Methylergometrine is a semisynthetic ergot alkaloid and a derivative of ergonovine and is used for the prevention and control of postpartum and post-abortion hemorrhage. In general, the effects of all the ergot alkaloids appear to results from their actions as partial agonists or antagonists at adrenergic, dopaminergic, and tryptaminergic receptors. The spectrum of effects depends on the agent, dosage, species, tissue, and experimental or physiological conditions. All of the alkaloids of ergot significantly increase the motor activity of the uterus. After small doses contractions are increased in force or frequency, or both, but are followed by a normal degree of relaxation. As the dose is increased, contractions become more forceful and prolonged, resting tonus is markedly increased, and sustained contracture can result.

Safety Profile

Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.

Metabolism

Hepatic, with extensive first-pass metabolism.

Properties of METHYLERGONOVINE

Melting point: 172-173℃ (decomposition)
Boiling point: 475.4°C (rough estimate)
alpha  D20 -45° (c = 0.4 in pyridine)
Density  1.1492 (rough estimate)
refractive index  1.6650 (estimate)
storage temp.  Desiccate at RT
pka pKa 6.65± 0.03(H2O,t =24,I<0.01)(Approximate)
color  Prisms from MeOH/Me2CO

Safety information for METHYLERGONOVINE

Computed Descriptors for METHYLERGONOVINE

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