Propantheline bromide

Chemical properties

white crystalline powder

The Uses of Propantheline bromide

Propantheline is an antimuscarinic agent used in the treatment of hyperhidrosis (excessive sweating), enuresis (involuntary urination) as well as cramps or spasms of the stomach, intestine and bladder.

The Uses of Propantheline bromide

anticholinergic

The Uses of Propantheline bromide

A muscarinic acetylcholine receptor antagonist

What are the applications of Application

Propantheline bromide is a muscarinic acetylcholine receptor antagonist

Definition

ChEBI: Propantheline bromide is a member of xanthenes.

brand name

Pro-Banthine (Searle).

General Description

White crystals or white powder. Melting point 159-161°C .Used therapeutically as an anticholinergic.

General Description

Propantheline bromide,2-hydroxy-ethyl)diisopropylmethylammonium bromidexanthene-9-carboxylate (Pro-Banthine), is prepared in amanner exactly analogous to that used for methanthelinebromide. It is a white, water-soluble, crystalline substance,with properties quite similar to those of methantheline bromide.Its chief difference from methantheline bromide is inits potency, which has been estimated variously to be 2 to5 times as great.

Air & Water Reactions

Water soluble.

Health Hazard

SYMPTOMS: Symptoms of exposure to Propantheline bromide include dilated pupils and blurred vision; increased intraocular tension and heart rate; hot, dry, red skin; dry mouth; disorientation; hallucinations; aggressive behavior; rapid pulse and respiration; convulsions; and coma.

Fire Hazard

Flash point data are not available for Propantheline bromide , but Propantheline bromide is probably combustible.

Biochem/physiol Actions

Inhibits action of acetylcholine at post-ganglionic synapses; muscarinic acetylcholine receptor antagonist; antispasmodic; reduces gastric acid secretion.

Veterinary Drugs and Treatments

In small animal medicine propantheline bromide has been used for its antispasmodic/antisecretory effects in the treatment of diarrhea. It is also employed in the treatment of hyperreflexic detrusor or urge incontinence and as oral treatment in anticholinergic responsive bradycardias. In horses, propantheline has been used intravenously to reduce colonic peristalsis and for relaxing the rectum to allow easier rectal examination and surgery.