Sulfamide

Chemical properties

White Solid

The Uses of Sulfamide

Sulfamide and its derivatives can also be used to prepare fused thiadiazine systems, Reaction with 2-aminoacetophenones affords IH-2,1,3-benzothia- diazine 2,2-dioxides 77 (65JOC3960). The corresponding 3,4-dihydro deriv- atives are readily available from 2-aminobenzylamines with either sulfuryl chloride (70M1443) or sulfamide (66USP3278532; 71MI055). These kinds of compounds can also be obtained from N-aryl-N'-alkylsulfamides and s-trioxane in a reaction involving cyclization by intramolecular sulfamido- methylation (79JOC2032) (Scheme 30).

The Uses of Sulfamide

A carbonic anhydrase inhibitor; used for treatment of cancer.

The Uses of Sulfamide

Similar to urea in many of its reactions, but is more acidic, and can act as a dibasic acid.

Definition

ChEBI: The simplest of the sulfamic acids consisting of a single sulfur atom covalently bound by single bonds to two amino groups and by double bonds to two oxygen atoms.

Preparation

Sulfamide is produced by the reaction of sulfuryl chloride with ammonia.

Purification Methods

Crystallise sulfamide from absolute EtOH. It decomposes at 250o. [Schenk in Handbook of Preparative Inorganic Chemistry (Ed. Brauer) Academic Press Vol I pp 482-483 1963.]