Methyl 3-mercaptopropionate
Synonym(s):3-Mercaptopropionic Acid Methyl Ester
- CAS NO.:2935-90-2
- Empirical Formula: C4H8O2S
- Molecular Weight: 120.17
- MDL number: MFCD00004895
- EINECS: 220-912-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-09-03 18:36:42
What is Methyl 3-mercaptopropionate?
Chemical properties
CLEAR COLORLESS LIQUID
The Uses of Methyl 3-mercaptopropionate
Methyl 3-Mercaptopropionate is used in the synthesis of thioisoindolinones.
The Uses of Methyl 3-mercaptopropionate
Methyl 3-mercaptopropionate is a click chemistry reagent used in the modification of oxazolines using thiol-ene click modification. It also has implications for self-assembled monolayers (SAMs). It is used in the colorimetric detection of mercury(II) in a high-salinity solution using gold nanoparticles.
The Uses of Methyl 3-mercaptopropionate
The Progress in Development of Dental Restorative Materials
What are the applications of Application
Methyl 3-mercaptopropionate is a compound for click chemistry and SAMs
What are the applications of Application
Methyl 3-mercaptopropionate is an important chemical raw material. It is an intermediate for preparing isothiazolinone and a raw material for preparing fine chemical 4-chloro-7-methylthiophene [3,2-D ] pyrimidine. The methyl 3-mercaptopropionate is a raw material for synthesizing a simvastatin side DMB-S-MMP3- [ (2, 2-dimethyl-1-oxobutyl) sulfur ] methyl propionate serving as a blood fat-reducing drug by an enzyme method. Simvastatin is listed in the essential drug list of the World Health Organization and belongs to one of the essential drugs of the basic medical system.
Flammability and Explosibility
Non flammable
Synthesis
The traditional synthetic method of the Methyl 3-mercaptopropionate comprises the steps of adding 2% -5% of concentrated sulfuric acid as a catalyst in an inert atmosphere, refluxing (65-70 ℃) for a reaction for 15 hours, evaporating reaction liquid to remove methanol after the reaction is finished, and then deacidifying; during the deacidification process, a large amount of deionized water is added for water washing, and when the pH of the water washing solution is close to neutrality, the Methyl 3-mercaptopropionate product is obtained by reduced pressure distillation. Another method for preparing Methyl 3-mercaptopropionate is by using a reactive distillation technology. Mix the reactant 3-mercaptopropionic acid and methanol, then perform pre-reaction through a fixed bed reactor filled with a catalyst to obtain a crude product of the methyl 3-mercaptopropionate. The crude product is pumped to the middle part of the reaction rectifying tower by a feeding pump and is input; fresh methanol and a water-carrying agent are input from the lower part of the reaction rectifying tower, a catalyst is arranged at the lower part of the reaction rectifying tower, and unreacted 3-mercaptopropionic acid in the crude product continuously reacts with methanol in a catalyst bed layer of the reaction rectifying tower; after the reaction is finished, excess methanol, water carrying agent and water are extracted from the upper part of the reaction rectifying tower, and the product Methyl 3-mercaptopropionate is extracted from the bottom of the tower.
Properties of Methyl 3-mercaptopropionate
Melting point: | 38 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4)) |
Boiling point: | 54-55 °C/14 mmHg (lit.) |
Density | 1.085 g/mL at 25 °C (lit.) |
refractive index | n |
Flash point: | 140 °F |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | soluble in Chloroform, Ethyl Acetate |
pka | 9.17±0.25(Predicted) |
form | Liquid |
color | Clear colorless |
Water Solubility | Soluble in water. |
BRN | 1742952 |
CAS DataBase Reference | 2935-90-2(CAS DataBase Reference) |
NIST Chemistry Reference | Propanoic acid, 3-mercapto-, methyl ester(2935-90-2) |
EPA Substance Registry System | Propanoic acid, 3-mercapto-, methyl ester (2935-90-2) |
Safety information for Methyl 3-mercaptopropionate
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 Environment GHS09 |
GHS Hazard Statements |
H312:Acute toxicity,dermal H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for Methyl 3-mercaptopropionate
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