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HomeProduct name listMethyl 3-mercaptopropionate

Methyl 3-mercaptopropionate

Synonym(s):3-Mercaptopropionic Acid Methyl Ester

  • CAS NO.:2935-90-2
  • Empirical Formula: C4H8O2S
  • Molecular Weight: 120.17
  • MDL number: MFCD00004895
  • EINECS: 220-912-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-09-03 18:36:42
Methyl 3-mercaptopropionate Structural

What is Methyl 3-mercaptopropionate?

Chemical properties

CLEAR COLORLESS LIQUID

The Uses of Methyl 3-mercaptopropionate

Methyl 3-Mercaptopropionate is used in the synthesis of thioisoindolinones.

The Uses of Methyl 3-mercaptopropionate

Methyl 3-mercaptopropionate is a click chemistry reagent used in the modification of oxazolines using thiol-ene click modification. It also has implications for self-assembled monolayers (SAMs). It is used in the colorimetric detection of mercury(II) in a high-salinity solution using gold nanoparticles.

The Uses of Methyl 3-mercaptopropionate

The Progress in Development of Dental Restorative Materials

What are the applications of Application

Methyl 3-mercaptopropionate is a compound for click chemistry and SAMs

What are the applications of Application

Methyl 3-mercaptopropionate is an important chemical raw material. It is an intermediate for preparing isothiazolinone and a raw material for preparing fine chemical 4-chloro-7-methylthiophene [3,2-D ] pyrimidine. The methyl 3-mercaptopropionate is a raw material for synthesizing a simvastatin side DMB-S-MMP3- [ (2, 2-dimethyl-1-oxobutyl) sulfur ] methyl propionate serving as a blood fat-reducing drug by an enzyme method. Simvastatin is listed in the essential drug list of the World Health Organization and belongs to one of the essential drugs of the basic medical system.

Flammability and Explosibility

Non flammable

Synthesis

The traditional synthetic method of the Methyl 3-mercaptopropionate comprises the steps of adding 2% -5% of concentrated sulfuric acid as a catalyst in an inert atmosphere, refluxing (65-70 ℃) for a reaction for 15 hours, evaporating reaction liquid to remove methanol after the reaction is finished, and then deacidifying; during the deacidification process, a large amount of deionized water is added for water washing, and when the pH of the water washing solution is close to neutrality, the Methyl 3-mercaptopropionate product is obtained by reduced pressure distillation. Another method for preparing Methyl 3-mercaptopropionate is by using a reactive distillation technology. Mix the reactant 3-mercaptopropionic acid and methanol, then perform pre-reaction through a fixed bed reactor filled with a catalyst to obtain a crude product of the methyl 3-mercaptopropionate. The crude product is pumped to the middle part of the reaction rectifying tower by a feeding pump and is input; fresh methanol and a water-carrying agent are input from the lower part of the reaction rectifying tower, a catalyst is arranged at the lower part of the reaction rectifying tower, and unreacted 3-mercaptopropionic acid in the crude product continuously reacts with methanol in a catalyst bed layer of the reaction rectifying tower; after the reaction is finished, excess methanol, water carrying agent and water are extracted from the upper part of the reaction rectifying tower, and the product Methyl 3-mercaptopropionate is extracted from the bottom of the tower.

Properties of Methyl 3-mercaptopropionate

Melting point: 38 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
Boiling point: 54-55 °C/14 mmHg (lit.)
Density  1.085 g/mL at 25 °C (lit.)
refractive index  n20/D 1.464(lit.)
Flash point: 140 °F
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  soluble in Chloroform, Ethyl Acetate
pka 9.17±0.25(Predicted)
form  Liquid
color  Clear colorless
Water Solubility  Soluble in water.
BRN  1742952
CAS DataBase Reference 2935-90-2(CAS DataBase Reference)
NIST Chemistry Reference Propanoic acid, 3-mercapto-, methyl ester(2935-90-2)
EPA Substance Registry System Propanoic acid, 3-mercapto-, methyl ester (2935-90-2)

Safety information for Methyl 3-mercaptopropionate

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Environment
GHS09
GHS Hazard Statements H312:Acute toxicity,dermal
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for Methyl 3-mercaptopropionate

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