6-Mercaptopurine
- CAS NO.:50-44-2
- Empirical Formula: C5H4N4S
- Molecular Weight: 152.18
- MDL number: MFCD00599524
- EINECS: 200-037-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-28 17:29:27
What is 6-Mercaptopurine ?
Absorption
Clinical studies have shown that the absorption of an oral dose of mercaptopurine in humans is incomplete and variable, averaging approximately 50% of the administered dose. The factors influencing absorption are unknown.
Toxicity
Signs and symptoms of overdosage may be immediate such as anorexia, nausea, vomiting, and diarrhea; or delayed such as myelosuppression, liver dysfunction, and gastroenteritis. The oral LD50 of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.
The Uses of 6-Mercaptopurine
Has a cytotoxicity effect
What are the applications of Application
6-Mercaptopurine is an inhibitor of de novo purine synthesis
Indications
For remission induction and maintenance therapy of acute lymphatic leukemia.
Background
An antimetabolite antineoplastic agent with immunosuppressant properties. It interferes with nucleic acid synthesis by inhibiting purine metabolism and is used, usually in combination with other drugs, in the treatment of or in remission maintenance programs for leukemia.
Pharmacokinetics
Mercaptopurine is one of a large series of purine analogues which interfere with nucleic acid biosynthesis and has been found active against human leukemias. It is an analogue of the purine bases adenine and hypoxanthine. It is not known exactly which of any one or more of the biochemical effects of mercaptopurine and its metabolites are directly or predominantly responsible for cell death.
Metabolism
Hepatic. Degradation primarily by xanthine oxidase. The catabolism of mercaptopurine and its metabolites is complex. In humans, after oral administration of 35S-6-mercaptopurine, urine contains intact mercaptopurine, thiouric acid (formed by direct oxidation by xanthine oxidase, probably via 6-mercapto-8-hydroxypurine), and a number of 6-methylated thiopurines. The methylthiopurines yield appreciable amounts of inorganic sulfate.
Properties of 6-Mercaptopurine
Melting point: | 241-244°C |
Boiling point: | 498.6±37.0 °C(Predicted) |
Density | 1.463 (estimate) |
storage temp. | Inert atmosphere,2-8°C |
solubility | DMSO : 35.71 mg/mL (234.66 mM; Need ultrasonic) |
form | solid |
Water Solubility | 124mg/L(25 ºC) |
Safety information for 6-Mercaptopurine
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 6-Mercaptopurine
Abamectin manufacturer
Aarti Industries Limited (AIL)
Surajlok Chemicals Pvt Ltd (Neon Laboratories Ltd)
Godavari Drugs Limited
Clickchem Research LLP
New Products
3-N-BOC-(S)-AMINO BUTYRONITRILE 4-Piperidinopiperidine 2-Methyl-4-nitrobenzoic acid 2-(4-bromophenyl)-2-methylpropanoic acid 4-Acetyl-2-methylbenzoicacid Acetyl-meldrum's acid Ethyl-4-Pyrazole carboxylate 2,6 Di acetylpyridine 2,6-Pyridinedimethanol 5,7-Dichloro-3H-Imidazo[4,5-B]Pyridine 5-Bromo-2-Methoxy-4-Methyl-3-Nitropyridine 2-Fluoro-5-Iodopyridine 2-Fluoro-5-Methylpyridine 2-Chloro-3-Bromo-5-Amiopyridine METHYL-4-(BUTYRYLAMINO)3-METHYL-5-NITROBENZOATE TRANS-CYCLOBUTANE-1,2- DICARBOXYLIC ACID 5-Nitro indazole R-(-)-5-(2-AMINO-PROPYL)-2-METHOXY-BENZENESULFONAMIDE 1,3-cyclohexanedione 4-Aminophenaethylalchol 3-NITRO-5-ACETYL IMINODIBENZYL (S)-(+)-4-BENZYL-2-OXAZOLIDINONE 4-FLUORO PHENYL MAGNESIUM BROMIDE 1.0 M IN THF 1-HYDROXY-4-METHYL6-(2,4,4-TRI METHYL PHENYL)-2-PYRIDONE MONO ETHANOL AMINE(PIROCTONE OLAMINE)Related products of tetrahydrofuran
You may like
-
50-44-2 6-Mercaptopurine 98%View Details
50-44-2 -
50-44-2 98%View Details
50-44-2 -
6-Mercaptopurine 98%View Details
50-44-2 -
50-44-2 98%View Details
50-44-2 -
6-Mercaptopurine 98%View Details
50-44-2 -
50-44-2 90 % AboveView Details
50-44-2 -
68915-31-1 99%View Details
68915-31-1 -
BENZALKONIUM CHLORIDE BKC 99%View Details
8001-54-5