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HomeProduct name listMETHACHOLINE BROMIDE

METHACHOLINE BROMIDE

Synonym(s):Methacholine bromide

  • CAS NO.:333-31-3
  • Empirical Formula: C8H18BrNO2
  • Molecular Weight: 240.14
  • MDL number: MFCD00011816
  • EINECS: 206-372-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
METHACHOLINE BROMIDE Structural

What is METHACHOLINE BROMIDE?

Chemical properties

WHITE CRYSTALLINE POWDER

The Uses of METHACHOLINE BROMIDE

Acetyl-β-methylcholine bromide (methylcholine bromide, methacholine bromide, Mch), a muscarinic acetylcholine receptor agonist, may be used in studies that involve the indentification, characterization and mechanism of action of muscarinic acetylcholine receptors. Mch may be used as a reference material in procedures used to detect or quantify its presence.

The Uses of METHACHOLINE BROMIDE

Methacholine is used only for bronchial hyperreactivity diagnostics. A synonym of this drug is provocholine.

What are the applications of Application

Acetyl β-methylcholine bromide is an acetylcholinesterase substrate

General Description

Methacholine can exist as (S) and (R) enantiomers.Although the chemical is used as the racemic mixture, itsmuscarinic activity resides principally in the (S)-isomer.The (S)/(R) ratio of muscarinic potency for these enantiomersis 240:1.

Mechanism of action

A minor structural change is the presence of a methyl group at the β-carbon atom of choline, which results in two main changes in the pharmacological profile of the molecule. Unlike acetylcholine, methacholine is hydrolyzed only by acetylcholinesterase, and the rate of hydrolysis is significantly less than with acetylcholine. Thus, the action of methacholine is significantly longer lasting than acetylcholine. Moreover, the presence of a methyl group at the β-carbon of choline provides the compound with a greater selectivity of action. Methacholine directly acts on muscarinic receptors of smooth muscle, glands,and the heart, and it has a very weak effect on nicotinic receptors of the autonomic ganglions of skeletal muscle.

Synthesis

Methacholine, 1-acetoxy-2-(N,N,N-trimethyl)propyl ammonium chloride (13.1.4) or acetyl-β-methylcholine can be synthesized by any of the methods described above [8]

Properties of METHACHOLINE BROMIDE

Melting point: 147-149 °C(lit.)
Density  1.3952 (rough estimate)
refractive index  1.6120 (estimate)
storage temp.  -20°C
form  Crystalline Powder
color  White to off-white
Water Solubility  almost transparency
Sensitive  Hygroscopic
BRN  6098010
EPA Substance Registry System 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide (333-31-3)

Safety information for METHACHOLINE BROMIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for METHACHOLINE BROMIDE

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