Glycopyrrolate
Synonym(s):Glycopyrrolate;glycopyrronium bromide;α-cyclopentylmandelic acid ester with 3-hydroxy-1,1-dimethylpyrrolidinium bromide;1-methyl-3-pyrrolidyl α-cyclopentylmandelate methobromide;1-methyl-3-pyrrolidyl α-phenyl-α-cyclopentylglycolate methobromide
- CAS NO.:596-51-0
- Empirical Formula: C19H28BrNO3-
- Molecular Weight: 398.33
- MDL number: MFCD00072137
- EINECS: 209-887-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-18 13:41:40
What is Glycopyrrolate?
Description
Glycopyrrolate is an antagonist of muscarinic acetylcholine receptors (mAChRs; Kis = 0.42, 1.77, 0.52, 0.78, and 1.29 nM for the M1-M5 receptors, respectively). It induces relaxation of precontracted isolated human bronchi when used at concentrations of 0.01, 0.1, or 1 μM. Glycopyrrolate reduces post-prandial gastric antral motility in dogs when administered at a dose of 0.01 mg/kg. It inhibits salivation in a rat model of sialorrhea induced by pilocarpine with an ED50 value of 0.74 μg/kg. Formulations containing glycopyrrolate have been used in the treatment of sialorrhea, peptic ulcers, and chronic obstructive pulmonary disease (COPD).
The Uses of Glycopyrrolate
Inhaled glycopyrrolate of is used to treat air flow blockage and prevent worsening of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. COPD is a long-term lung disease that causes bronchospasm (difficulty with breathing).
Properties of Glycopyrrolate
Melting point: | 192-195°C |
Density | 1.3222 (rough estimate) |
storage temp. | 2-8°C |
solubility | H2O: ≥24mg/mL |
form | powder |
color | white to tan |
Safety information for Glycopyrrolate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Glycopyrrolate
InChIKey | VPNYRYCIDCJBOM-UHFFFAOYSA-M |
SMILES | C(O)(C(=O)OC1CC[N+](C)(C)C1)(C1=CC=CC=C1)C1CCCC1.[Br-] |
Abamectin manufacturer
Jigs Chemical ltd
SNA HEALTHCARE PVT LTD
SUJALAM CHEMICALS
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