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HomeProduct name listBENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE

BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE

  • CAS NO.:125-51-9
  • Empirical Formula: C22H28BrNO3
  • Molecular Weight: 434.37
  • MDL number: MFCD00079275
  • EINECS: 204-741-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 15:05:47
BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE Structural

What is BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE?

Originator

Piptal ,Merrell National ,US ,1955

The Uses of BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE

antispasmodic

The Uses of BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE

Piptalake is used in the treatment with copper-tolylterpyridine and platinum-tolylterpyridine that targets telomeres and telomerase for regulation of chromosome mis-segregation rates for cancer therapy.

Manufacturing Process

N-ethyl-3-chloropiperidine was prepared according to the method of Fuson and Zirkle described in Volume 70, J. Am. Chem. Soc., p 2760. 12.0 g (0.081 mol) of N-ethyl-3-chloropiperidine was mixed with 18.6 g (0.081 mol) of benzilic acid and 80 cc of anhydrous isopropyl alcohol as a solvent. The mixture was refluxed for 72 hours. The solution was then filtered and concentrated at 30 mm of mercury. The concentrate was dissolved in water, acidified with hydrochloric acid and extracted with ether to remove theThe aqueous layer was neutralized with sodium bicarbonate and the product was extracted with ether. The ethereal solution of the product was dried with potassium carbonate, the ether was removed by distillation and the residue was distilled at 0.12 to 0.18 mm of mercury, the BP being 194° to 198°C. A yield of 16.5 g (60% of theoretical) of N-ethyl-3-piperidyl-benzilate was obtained.
34 g (0.1 mol) of the basic ester is dissolved in 75 cc of isopropyl alcohol and treated with 9.5 g (0.1 mol) of methyl bromide. The mixture is allowed to stand at room temperature until precipitation is complete. The product is removed by filtration and washed with isopropyl alcohol, yield 33 g, MP 175° to 177°C. On recrystallization from isopropyl alcohol, the MP was raised to 179° to 180°C dec.

brand name

Piptal (Marion Merrell Dow).

Therapeutic Function

Spasmolytic

Properties of BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE

Melting point: 179-180°
form  powder
color  white

Safety information for BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for BENZILIC ACID 1-ETHYLPIPERIDIN-3-YL ESTER METHOBROMIDE

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