ME0328
Synonym(s):(S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide
- CAS NO.：1445251-22-8
- Empirical Formula: C19H19N3O2
- Molecular Weight: 321.37
- MDL number: MFCD27991291
- EINECS: 808-923-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is ME0328?
Description
The poly(ADP-ribose) polymerases (PARPs) are enzymes with roles in DNA repair, apoptosis, inflammation, and other cellular events, particularly in response to reactive oxygen and nitrogen species. ME0328 is an inhibitor of PARP3 (IC50 = 0.89 μM), which is a regulator of DNA repair and mitotic progression. It displays selectivity for PARP3 over 12 other PARP family members. ME0328 is cell permeable and elicits PARP3-specific effects at submicromolar concentrations.
The Uses of ME0328
ME0328 is a potent poly ADP ribose polymerase (PARP) inhibitor with selectivity towards the human ADP-Ribosyltransferase ARTD3/PARP3.
References
1) Lindgren?et al. (2013),?PARP Inhibitor with Selectivity Toward ADP-Ribosyltransferase ART3/PARP3; ACS Chem. Biol.,8?1689
Properties of ME0328
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | white to beige |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
Safety information for ME0328
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for ME0328
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION SODIUM METHYL PARABEN Methylcobalamin (vitamin B12) Diclofenac Sodium SODIUM VALPROATE Racecadotril XANTHAN GUM 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
You may like
-
ME0328 CAS 1445251-22-8View Details
1445251-22-8 -
3-Bromo-2-hydroxybenzeneacetic acid 98%View Details
88491-46-7 -
1805639-70-6 98%View Details
1805639-70-6 -
2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%View Details
1307449-08-6 -
25408-95-1 98%View Details
25408-95-1 -
1-(3-Chloro-2-hydroxyphenyl)-2-propanone 98%View Details
1784294-80-9 -
99903-60-3 98%View Details
99903-60-3 -
5-Fluoro-2-iodo-3-methylaniline 1823368-42-8 98%View Details
1823368-42-8
Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.