Manidipine hydrochloride

Synonym(s):1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid hydrchloride, 2-[4-(diphenylmethyl)-1-piperazinyl]ethyl methyl ester;3-(2-(4-Benzhydrylpiperazin-1-yl)ethyl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrchloride;Franidipine hydrchloride;

CAS NO.：89226-75-5
Empirical Formula: C35H40Cl2N4O6
Molecular Weight: 683.62
MDL number: MFCD00896434
EINECS: 680-304-3
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is Manidipine hydrochloride?

Description

Manidipine (89226-75-5) is a clinically useful antihypertensive.1,2 It is an inhibitor of L- and T-type calcium channels with high selectivity for vasculature.? Manidipine has recently been found to be an inhibitor (IC50 = 4.8 μM) of the SARS-CoV-2 main protease, 3CLpro.3 It also acts as an early entry inhibitor of human cytomegalovirus (EC50 = 3.57 μM) via inhibition of the Immediate-Early 2 (IE2) protein.4

The Uses of Manidipine hydrochloride

aldosterone antagonist

The Uses of Manidipine hydrochloride

Manidipine Dihydrochloride is a metabolite of Manidipine (M16400), a dihydropyridine calcium channel blocker that exhibits antihypertensive properties.

What are the applications of Application

Manidipine dihydrochloride is a calcium channel protein inhibitor and antagonist

Definition

ChEBI: Manidipine dihydrochloride is a diarylmethane.

References

Kakihana et al. (1988), Antihypertensive effect of CV-4093·2HCl, a new calcium antagonist, in three rat models of hypertension; Jpn. J. Pharmacol., 48 223 McKeage (2004), Manidipine: a review of its use in the management of hypertension; Drugs, 64 1923 Ghahremanpour et al. (2020), Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2; ACS Med. Chem. Lett., 11 2526 Mercorelli et al. (2018), Repurposing the clinically approved calcium antagonist manidipine dihydrochloride as a new early entry inhibitor of human cytomegalovirus targeting the Immediate-Early 2 (IE2) protein; Antiviral Res., 150 130

Properties of Manidipine hydrochloride

Melting point:	157-163°; mp 174-180°; mp 167-170°
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Soluble in DMSO (>25 mg/ml)
form	solid
color	White
Water Solubility	Soluble in DMSO. Slightly soluble in water and ethanol /n
Merck	14,5743
Stability:	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference	89226-75-5(CAS DataBase Reference)

Safety information for Manidipine hydrochloride

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H301:Acute toxicity,oral H336:Specific target organ toxicity,single exposure; Narcotic effects
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P501:Dispose of contents/container to..…