Magnesium acetate tetrahydrate

Absorption

Intestinal absorption is achieved mainly through passive diffusion.

Toxicity

Predicted oral LD50 value is >2000mg/kg. In case of mild to moderate toxicity, it may cause irritation in case of skin or eye contact,and nausea or vomiting from ingestion and inhalation. In overdose, magnesium impairs neuromuscular transmission, manifested as weakness and hyporeflexia. Early manifestations of severe toxicity are lethargy, hyporeflexia, followed by weakness, paralysis, hypotension, ECG changes (prolonged PR and QRS intervals), CNS depression, seizures, and respiratory depression.

Chemical properties

Colourless crystals or white or almost white, crystalline powder.

The Uses of Magnesium acetate tetrahydrate

Used in dialysis solutions.

The Uses of Magnesium acetate tetrahydrate

Magnesium acetate [Mg(C2H3O2)2?4H2O] is used in the textile industry as a mordant (“fixes” dyes so that they will not run). It is also used as a deodorant and antiseptic.

The Uses of Magnesium acetate tetrahydrate

Used as a source of magnesium in biological reactions, and as a source of acetate ion in chemical transformations. Acts as an emission control agent in coal combustion process to reduce acid rain. It is involved in glass formation process via the thermal decomposition of solids.

Background

Magnesium acetate tetrahydrate is a hydrated form of anhydrous magnesium acetate salt with the chemical formula of Mg(CH3COO)2 ? 4H2O. As a salt form of magnesium, magnesium acetate is one of the bioavailable forms of magnesium and forms a very water soluble compound. Magnesium is an essential element and second most abundant cation in the body that plays a key role in maintaining normal cellular function such as production of ATP and efficient enzyme activity. Magnesium acetate tetrahydrate can be used as an electrolyte supplementation or a reagent in molecular biology experiments.

Indications

Used as magnesium salf-containing laxatives to prevent constipation. It can bring synergistic effect to restore normal bowel function when using in combination with aluminum salts that induce bowel retention . Magnesium acetate tetrahydrate is used as a source of water and electrolytes when combined with dextrose and other salts to form intravenous infusions. This injection can be used for patients with carbohydrate or magnesium deficiency, insulin hypoglycemia, constipation or hypertension during pregnancy.

What are the applications of Application

Magnesium Acetate Tetrahydrate, Molecular Biology Grade is DNase, RNase and protease free

Pharmacokinetics

Magnesium is an essential cofactor for many enzymatic reactions such as protein synthesis and ATP production. It also participates in adenylyl cyclase pathway and tyrosine kinase signalling pathways. Magnesium may also play a role in regulating glucose metabolism. It serves as an essential cation for a number of biochemical processes involved in nerve signaling, bone mineralization and muscle contractions.

Metabolism

Not Available

Purification Methods

Crystallise it from anhydrous acetic acid, then dry it under vacuum for 24hours at 100o. [Nencollas J Chem Soc 744 1956, Beilstein 2 IV 113.]