Magaldrate
Synonym(s):Aluminum magnesium hydroxide sulfate hydrate
- CAS NO.：74978-16-8
- Empirical Formula: Al5H31Mg10O39S2.xH2O
- Molecular Weight: 0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-19 15:37:50
What is Magaldrate?
Description
Magaldrate (hydroxymagnesium aluminate) insoluble in water, white, odorless crystalline powder, soluble in dilute mineral acids. Magaldrate favorably combines the strongly basic properties of magnesium located in the crystal core with the less basic properties of aluminum ions surrounding the former in a layered lattice. The magaldrate layered lattice consists of recurrent stacks of octahedral basic layers with an excess of positive charges 5+ on the outer gel surface , . These charges electrostatically interact with negative charges of the gastric mucus layer to favorably increase the antacid’s retention time in the stomach .
Chemical properties
White or almost white, crystalline powder.
The Uses of Magaldrate
Antacid.
Background
Magaldrate is an antacid drug used for the treatment of esophagitis, duodenal and gastric ulcers, and gastroesophageal reflux. Magaldrate has been discontinued in the US market.
brand name
Riopan (Whitehall-Robins).
Metabolism
Not Available
Properties of Magaldrate
| solubility | Practically insoluble in water and in ethanol (96 per cent). It is soluble in dilute mineral acids. |
Safety information for Magaldrate
Computed Descriptors for Magaldrate
Magaldrate manufacturer
Ralington Pharma
Nitika Pharmaceutical Specialities Pvt Ltd
Vasundhara Rasayans Ltd
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