Liranaftate
- CAS NO.：88678-31-3
- Empirical Formula: C18H20N2O2S
- Molecular Weight: 328.43
- MDL number: MFCD00865576
- EINECS: 000-000-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-23 17:50:46
What is Liranaftate?
Description
Liranaftate was launched in Japan as a new topical antifungal for the treatment of dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can be prepared by condensation of 5,6，7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl chloride. It is a potent and specific inhibitor of squalene epoxidase and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels. Liranaftate was found to be significantly more active than the other thiocarbamate tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed.
Chemical properties
White Crystalline Solid
Originator
Tosoh (Japan)
The Uses of Liranaftate
A squalene epoxidase inhibitor. Used as an antifungal
The Uses of Liranaftate
A squalene epoxidase inhibitor. Used as an antifungal.
What are the applications of Application
Liranaftate is a squalene epoxidase inhibitor
Definition
ChEBI: Liranaftate is a member of tetralins.
brand name
Zefnart
Properties of Liranaftate
| Melting point: | 98.5-99.5°C |
| Boiling point: | 462.5±55.0 °C(Predicted) |
| Density | 1.240±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
| form | Solid |
| pka | 1.24±0.10(Predicted) |
| color | Off-White |
| Merck | 14,5515 |
Safety information for Liranaftate
Computed Descriptors for Liranaftate
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