Liranaftate
- CAS NO.:88678-31-3
- Empirical Formula: C18H20N2O2S
- Molecular Weight: 328.43
- MDL number: MFCD00865576
- EINECS: 000-000-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-04 20:04:50
What is Liranaftate?
Description
Liranaftate was launched in Japan as a new topical antifungal for the treatment of dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can be prepared by condensation of 5,6,7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl chloride. It is a potent and specific inhibitor of squalene epoxidase and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels. Liranaftate was found to be significantly more active than the other thiocarbamate tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed.
Chemical properties
White Crystalline Solid
Originator
Tosoh (Japan)
The Uses of Liranaftate
A squalene epoxidase inhibitor. Used as an antifungal
The Uses of Liranaftate
A squalene epoxidase inhibitor. Used as an antifungal.
What are the applications of Application
Liranaftate is a squalene epoxidase inhibitor
Definition
ChEBI: Liranaftate is a member of tetralins.
brand name
Zefnart
Properties of Liranaftate
Melting point: | 98.5-99.5°C |
Boiling point: | 462.5±55.0 °C(Predicted) |
Density | 1.240±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly, Heated) |
form | Solid |
pka | 1.24±0.10(Predicted) |
color | Off-White |
Merck | 14,5515 |
Safety information for Liranaftate
Computed Descriptors for Liranaftate
New Products
(R)-(-)-2-Amino-1-propanol Tetrahydro-4H-pyran-4-one Bromine 99.5% AR (4 x 500ml) Linseed Oil Extrapure Hydrogen Sulphide Solution Oxalic Acid 0.05 mol/L (0.01N) Solution EDTA 0.1 mol/L (0.2N) for 1000 ml Ferroin 0.025M Solution AR 1,2,3,4-Tetrahydrocarbazol-4-one 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid Acetone Isobutryl oxime ester Sodium Amino Salicylate Dihydrate (PAS Sodium) IP/BP/USP/EP Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Spirulina (Arthrospira platensis) Powder Trikatu Extract Thymol Oil Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride 5-NitrosalicylaldehydeRelated products of tetrahydrofuran
You may like
-
Liranaftate 95% CAS 88678-31-3View Details
88678-31-3 -
Liranaftate CAS 88678-31-3View Details
88678-31-3 -
7726-95-6 Bromine 99.5% AR (4 x 500ml) 99%View Details
7726-95-6 -
Formamide 99%View Details
75-12-7 -
85-81-4 6-Methoxy-8-Nitroquinoline 99%View Details
85-81-4 -
3-Bromo-4,5-Dihydro-1H-Benzo[B]Azepin-2(3H)-One 99%View Details
86499-96-9 -
29943-42-8 Tetrahydro-4H-pyran-4-one 98+View Details
29943-42-8 -
35320-23-1 98+View Details
35320-23-1