Liranaftate

CAS NO.：88678-31-3
Empirical Formula: C18H20N2O2S
Molecular Weight: 328.43
MDL number: MFCD00865576
EINECS: 000-000-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is Liranaftate?

Description

Liranaftate was launched in Japan as a new topical antifungal for the treatment of dermatophycoses. This compound belonging to the thiocarbamate class of antifungals can be prepared by condensation of 5,6，7,8-tetrahydro-2-naphthol with the corresponding Npyridylthiocarbamoyl chloride. It is a potent and specific inhibitor of squalene epoxidase and consequently a blocker of ergosterol biosynthesis in fungi, without any detectable effect on mammalian cholesterol biosynthesis in rat liver at therapeutic dose levels. Liranaftate was found to be significantly more active than the other thiocarbamate tolnaftate against several dermatophytes, including Trichophyton mentagrophyfes, and against certain yeasts, such as Crypfococcus neoformans. On the other hand, it was inactive against a variety of Gram-positive and negative bacteria. When applicated as a 1 or 2% cream during clinical trials, it was well tolerated and no systemic absorption was observed.

Chemical properties

White Crystalline Solid

Originator

Tosoh (Japan)

The Uses of Liranaftate

A squalene epoxidase inhibitor. Used as an antifungal

The Uses of Liranaftate

A squalene epoxidase inhibitor. Used as an antifungal.

What are the applications of Application

Liranaftate is a squalene epoxidase inhibitor

Definition

ChEBI: Liranaftate is a member of tetralins.

brand name

Zefnart

Properties of Liranaftate

Melting point:	98.5-99.5°C
Boiling point:	462.5±55.0 °C(Predicted)
Density	1.240±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
form	Solid
pka	1.24±0.10(Predicted)
color	Off-White
Merck	14,5515