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HomeProduct name listLidocaine hydrochloride

Lidocaine hydrochloride

Synonym(s):2-Diethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate;Lignocaine hydrochloride monohydrate;Xylocaine hydrochloride monohydrate

  • CAS NO.:6108-05-0
  • Empirical Formula: C14H25ClN2O2
  • Molecular Weight: 288.82
  • MDL number: MFCD00150329
  • EINECS: 612-079-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-25 18:09:02
Lidocaine hydrochloride Structural

What is Lidocaine hydrochloride?

Chemical properties

Linocaine hydrochloride is a white or almost white, crystalline powder with slightly bitter and numbing taste. Soluble in water, ethanol and organic solvents, insoluble in ether. The aqueous solution does not decompose under acid and alkali conditions, and it rarely deteriorates after repeated autoclaving.

The Uses of Lidocaine hydrochloride

Linocaine hydrochloride is a fast voltage-gated sodium channel blocker that used in Local anesthesia and heart rhythm disorders. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

What are the applications of Application

Lidocaine hydrochloride monohydrate is a fast voltage-gated sodium channel blocker

Definition

ChEBI: Linocaine hydrochloride is the monohydrate form of lidocaine hydrochloride. It is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of Procaine but its duration of action is shorter than that of bupivacaine or prilocaine.

What are the applications of Application

Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic.

brand name

Alpha caine Hydrochloride (Carlisle); Anestacon (Polymedica); Laryng-O-Jet (International Medication); Lidocaton (Phar maton); Lidopen (Meridian); Xylocaine (Abraxis); Xylo caine (AstraZeneca); Xylocaine (Dentsply).

Contact allergens

Linocaine hydrochloride is an anesthetic of the amide group, like articaine or bupivacaine. Immediate-type IgE-dependent reactions are rare, and delayed-type contact dermatitis is exceptional. Cross-reactivity between the different amide anesthetics is not systematic.

Synthesis

A method for preparing Lidocaine hydrochloride is described as follows. The method comprises the following steps: by taking 2,6-xylenol as a raw material, Pd/C as a primary catalyst and 2,6-dimethylcyclohexanone as a promoter, performing liquid phase amination with ammonia water at high temperature, thereby obtaining a midbody 2,6-dimethylaniline; enabling sodium methylate, 2,6-dimethylaniline and N,N-lignocaine methyl acetate as raw materials to react at 90-95 DEGC, distilling while reaction is performed to remove methanol till no methanol can be evaporated out, continuously reacting for 30 minutes, cooling to the room temperature, adding dichloroethane, washing with water, and leaving to stand to layer, thereby obtaining an organic layer, namely, a lidocaine based dichloroethane solution; further adding hydrochloric acid into the lidocaine based dichloroethane solution, adjusting the pH value to be 3.5-4 by using hydrogen chloride, adding activated carbon to reflux for 20-40 minutes, filtering, concentrating the filtrate, cooling, crystallizing, and dying, thereby obtaining Lidocaine hydrochloride.

Mode of action

Lidocaine Hydrochloride is the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability.

Properties of Lidocaine hydrochloride

Melting point: 75-79℃
storage temp.  2-8°C
solubility  H2O: soluble
form  solid
color  white
Water Solubility  Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether.
InChI InChI=1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2
CAS DataBase Reference 6108-05-0(CAS DataBase Reference)

Safety information for Lidocaine hydrochloride

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral

Computed Descriptors for Lidocaine hydrochloride

InChIKey YECIFGHRMFEPJK-UHFFFAOYSA-N
SMILES C1(C(C)=CC=CC=1C)NC(=O)CN(CC)CC.O.Cl

Lidocaine hydrochloride manufacturer

Apex Healthcare Limited

1Y
Phone:+91-9825711244
Whatsapp: +91 99825711244
product: 6108-05-0 98%
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Alex Pharmachem Pvt. Ltd

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Phone:+91-9974615135
Whatsapp: +91 9974615135
product: Lidocaine hydrochloride monohydrate 98%
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Chemino Pharma Ltd

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Phone:+91-8689897373
product: Lidocaine hydrochloride monohydrate 6108-05-0 98%
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Mahendra Chemicals

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Phone:+91-9824019625
Whatsapp: +91 9824019625
product: 6108-05-0 Lidocaine hydrochloride monohydrate 98%
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Meck Pharmaceuticals and Chemicals Pvt. Ltd.

1Y
Phone:+91-9898540709
Whatsapp: +91 9898540709
product: 6108-05-0 98%
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Technodrugs Intermediates Pvt. Ltd.

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Phone:+91-2226743405
product: Lidocaine hydrochloride monohydrate 98%
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Ralington Pharma

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Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: Lidocaine hydrochloride monohydrate 6108-05-0 98%
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Chemixl intermediates pvt Ltd

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Phone:+91-6352568618
Whatsapp: +91- 9824173530
product: 6108-05-0 Lidocaine Hydrochloride 98%
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