4-Hydroxyaniline hydrochloride

Synonym(s):4-Aminophenol hydrochloride;4-Aminophenol hydrochloride, 4-Hydroxyaniline hydrochloride;4-Hydroxyaniline hydrochloride;4-Hydroxyanilinium chloride

CAS NO.：51-78-5
Empirical Formula: C6H8ClNO
Molecular Weight: 145.59
MDL number: MFCD00012996
EINECS: 200-122-6
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-15 10:43:20

4-Hydroxyaniline hydrochloride Structural

What is 4-Hydroxyaniline hydrochloride?

Chemical properties

Off white powder

The Uses of 4-Hydroxyaniline hydrochloride

4-Aminophenol may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations using surface enhanced Raman scattering method.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. 4-Aminophenol hydrochloride can be used to study cell biology, bioactive small molecules, chemical synthesis, organic building blocks, oxygen compounds and phenols.

Safety Profile

Moderately toxic byintraperitoneal route. Mutation data reported. Whenheated to decomposition it emits very toxic fumes of HCland NO_x.

Purification Methods

Purify the salt by treating an aqueous solution with saturated Na2S2O3, filtering under N2, then recrystallising it from 50% EtOH twice and once from absolute EtOH [Livingston & Ke J Am Chem Soc 72 909 1950]. [Beilstein 13 III 993.]

Properties of 4-Hydroxyaniline hydrochloride

Melting point:	302 °C
Boiling point:	306°C (decomp)
storage temp.	Store below +30°C.
solubility	DMSO (Slightly), Methanol (Slightly)
form	powder
color	gray
Water Solubility	soluble
Merck	14,462
BRN	3911747
Stability:	Stable, but hygroscopic, air and light sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference	51-78-5(CAS DataBase Reference)
EPA Substance Registry System	4-Aminophenol hydrochloride (51-78-5)

Safety information for 4-Hydroxyaniline hydrochloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H341:Germ cell mutagenicity H351:Carcinogenicity H372:Specific target organ toxicity, repeated exposure H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection.