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HomeProduct name list4-methylquinoline

4-methylquinoline

Synonym(s):4-Methylquinoline;Lepidine

  • CAS NO.:491-35-0
  • Empirical Formula: C10H9N
  • Molecular Weight: 143.19
  • MDL number: MFCD00006784
  • EINECS: 207-734-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-10-21 16:57:38
4-methylquinoline Structural

What is 4-methylquinoline?

Description

Refer to 6-METHYLQUINOLINE.

Chemical properties

clear slightly yellow to brown liquid

Physical properties

4-Methylquinoline is a colorless liquid with a weak quinoline-like odor. It is slightly soluble in water, miscible with many organic solvents, and volatile in steam.

The Uses of 4-methylquinoline

Lepidine is used in the preparation of certain dyes.

The Uses of 4-methylquinoline

4-Methylquinoline is used as a reagent in the synthesis of azetidine based ene-amides as potent bacterial enoyl ACP reductase inhibitors. Also used as a reagent in the synthesis of cyanine-styryl dyes with enhanced photostability for fluorescent DNA imaging.

Definition

ChEBI: A methylquinoline carrying a methyl substituent at position 4.

Production Methods

4-Methylquinoline can be recovered from the highest-boiling fraction of the coal-tar quinoline bases via its o-cresol addition compound. It can be synthesized by condensation of aniline and methyl vinyl ketone.

Synthesis Reference(s)

Tetrahedron Letters, 28, p. 5291, 1987 DOI: 10.1016/S0040-4039(00)96710-8

General Description

Synthesis of lepidine from 4-anilinobutan-2-one in ethanol in the presence of HCl or FeCl3 has been reported. Nitration of lepidine has been reported.

Purification Methods

Reflux lepidine with BaO, then fractionally distil it. Further purify it via its recrystallised dichromate salt (m 138o) (from H2O). [Cumper et al. J Chem Soc 1176 1962.] [Beilstein 20 III/IV 3477, 20/7 V 389.]

Properties of 4-methylquinoline

Melting point: 9-10 °C(lit.)
Boiling point: 261-263 °C(lit.)
Density  1.083 g/mL at 25 °C(lit.)
refractive index  n20/D 1.620(lit.)
Flash point: >230 °F
storage temp.  Refrigerator
solubility  Chloroform (Slightly), Methanol (Slightly)
form  Liquid
pka 5.67(at 20℃)
color  Pale Orange
Odor at 100.00 %. burnt oily herbal floral sweet
Water Solubility  Slightly soluble
Sensitive  Light Sensitive
Merck  14,5441
BRN  110926
CAS DataBase Reference 491-35-0(CAS DataBase Reference)
NIST Chemistry Reference Quinoline, 4-methyl-(491-35-0)
EPA Substance Registry System Quinoline, 4-methyl- (491-35-0)

Safety information for 4-methylquinoline

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P271:Use only outdoors or in a well-ventilated area.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for 4-methylquinoline

InChIKey MUDSDYNRBDKLGK-UHFFFAOYSA-N

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