4-methylquinoline
Synonym(s):4-Methylquinoline;Lepidine
- CAS NO.:491-35-0
- Empirical Formula: C10H9N
- Molecular Weight: 143.19
- MDL number: MFCD00006784
- EINECS: 207-734-2
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-10-21 16:57:38
What is 4-methylquinoline?
Description
Refer to 6-METHYLQUINOLINE.
Chemical properties
clear slightly yellow to brown liquid
Physical properties
4-Methylquinoline is a colorless liquid with a weak quinoline-like odor. It is slightly soluble in water, miscible with many organic solvents, and volatile in steam.
The Uses of 4-methylquinoline
Lepidine is used in the preparation of certain dyes.
The Uses of 4-methylquinoline
4-Methylquinoline is used as a reagent in the synthesis of azetidine based ene-amides as potent bacterial enoyl ACP reductase inhibitors. Also used as a reagent in the synthesis of cyanine-styryl dyes with enhanced photostability for fluorescent DNA imaging.
Definition
ChEBI: A methylquinoline carrying a methyl substituent at position 4.
Production Methods
4-Methylquinoline can be recovered from the highest-boiling fraction of the coal-tar quinoline bases via its o-cresol addition compound. It can be synthesized by condensation of aniline and methyl vinyl ketone.
Synthesis Reference(s)
Tetrahedron Letters, 28, p. 5291, 1987 DOI: 10.1016/S0040-4039(00)96710-8
General Description
Synthesis of lepidine from 4-anilinobutan-2-one in ethanol in the presence of HCl or FeCl3 has been reported. Nitration of lepidine has been reported.
Purification Methods
Reflux lepidine with BaO, then fractionally distil it. Further purify it via its recrystallised dichromate salt (m 138o) (from H2O). [Cumper et al. J Chem Soc 1176 1962.] [Beilstein 20 III/IV 3477, 20/7 V 389.]
Properties of 4-methylquinoline
Melting point: | 9-10 °C(lit.) |
Boiling point: | 261-263 °C(lit.) |
Density | 1.083 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | >230 °F |
storage temp. | Refrigerator |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | Liquid |
pka | 5.67(at 20℃) |
color | Pale Orange |
Odor | at 100.00 %. burnt oily herbal floral sweet |
Water Solubility | Slightly soluble |
Sensitive | Light Sensitive |
Merck | 14,5441 |
BRN | 110926 |
CAS DataBase Reference | 491-35-0(CAS DataBase Reference) |
NIST Chemistry Reference | Quinoline, 4-methyl-(491-35-0) |
EPA Substance Registry System | Quinoline, 4-methyl- (491-35-0) |
Safety information for 4-methylquinoline
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 4-methylquinoline
InChIKey | MUDSDYNRBDKLGK-UHFFFAOYSA-N |
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