8-Methylquinoline
Synonym(s):o-Toluquinoline
- CAS NO.:611-32-5
- Empirical Formula: C10H9N
- Molecular Weight: 143.19
- MDL number: MFCD00006810
- EINECS: 210-264-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-08-21 22:41:43
What is 8-Methylquinoline?
Chemical properties
clear yellow liquid
The Uses of 8-Methylquinoline
8-Methylquinoline has been used in preparation of osmium chloridophosphine complexes, as quinoline carbene tautomers.Tumorigenic potential of 8-methylquinoline has been evaluated in newborn CD-1 mice and Sprague-Dawley rats.
The Uses of 8-Methylquinoline
8-Methylquinoline is used in QSAR treatment of mutagenicity and cytotoxicity of quinolines.
Definition
ChEBI: A methylquinoline carrying a methyl substituent at position 8.
Synthesis Reference(s)
The Journal of Organic Chemistry, 45, p. 1514, 1980 DOI: 10.1021/jo01296a035
General Description
Yellow liquid or oil.
Air & Water Reactions
Slightly soluble in water.
Reactivity Profile
8-Methylquinoline may be sensitive to exposure to light. May react vigorously with strong oxidizing agents and strong acids . Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Fire Hazard
8-Methylquinoline is combustible.
Purification Methods
Purify it as for 2-methylquinoline. The phosphate and picrate have m 158o and m 201o, respectively. [Beilstein 20 III/IV 3500, 20/7 V 405.]
Properties of 8-Methylquinoline
Melting point: | -80 °C |
Boiling point: | 245 °C |
Density | 1.052 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | 221 °F |
storage temp. | Room Temperature |
solubility | Chloroform, Methanol |
form | Liquid |
pka | 5.03±0.17(Predicted) |
color | Clear yellow |
Specific Gravity | 1.052 |
Water Solubility | 0.1-0.5 g/100 mL at 17 ºC |
BRN | 111340 |
CAS DataBase Reference | 611-32-5(CAS DataBase Reference) |
NIST Chemistry Reference | Quinoline, 8-methyl-(611-32-5) |
EPA Substance Registry System | 8-Methylquinoline (611-32-5) |
Safety information for 8-Methylquinoline
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for 8-Methylquinoline
InChIKey | JRLTTZUODKEYDH-UHFFFAOYSA-N |
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