LDN-193189
- CAS NO.:1062368-24-4
- Empirical Formula: C25H22N6
- Molecular Weight: 406.48
- MDL number: MFCD17169988
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:16
What is LDN-193189?
Description
Normal development and tissue repair are controlled in part by SMADs, a family of intracellular proteins that are activated by signaling via serine/threonine kinase receptors of the TGF-
The Uses of LDN-193189
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline, is a selective inhibitor of bone morphogenetic protein (BMP) pathway, useful in the treatment of diseases. Potent BMP Inhibitor?, Promotes hPSC Neural Induction?.
Definition
ChEBI: 4-[6-[4-(1-piperazinyl)phenyl]-3-pyrazolo[1,5-a]pyrimidinyl]quinoline is a member of pyrimidines.
Biochem/physiol Actions
Although LDN193189 is a structural analog of dorsomorphin, these two drugs are found to establish different cellular responses. In vitro analysis reveals that LDN193189 inhibits a number of intracellular kinases such as, mitogen activated protein kinase 14 and 8 ( p38and c-Jun N-terminal kinase respectively), as well as those associated with AKT (serine/threonine kinase) and mTOR (mammalian target of rapamycin) signaling mechanisms. LDN193189 is known to elevate the levels hemoglobin and thus helps to prevent the onset of anemia of inflammation.
References
[1] yu pb, deng dy, lai cs, hong cc, cuny gd, bouxsein ml, hong dw, mcmanus pm, katagiri t, sachidanandan c, kamiya n, fukuda t, mishina y, peterson rt, bloch kd. bmp type i receptor inhibition reduces heterotopic [corrected] ossification. nat med. 2008 dec;14(12):1363-9.
[2] boergermann jh1, kopf j, yu pb, knaus p. dorsomorphin and ldn-193189 inhibit bmp-mediated smad, p38 and akt signalling in c2c12 cells. int j biochem cell biol. 2010 nov;42(11):1802-7.
[3] helbing t1, herold em, hornstein a, wintrich s, heinke j, grundmann s, patterson c, bode c, moser m. inhibition of bmp activity protects epithelial barrier function in lung injury. j pathol. 2013 sep;231(1):105-16. doi: 10.1002/path.4215. epub 2013 jul 10.
Properties of LDN-193189
Density | 1.33 |
storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
solubility | H2O: soluble5mg/mL, clear (warmed) |
form | powder |
pka | 8.79±0.10(Predicted) |
color | yellow to orange |
Safety information for LDN-193189
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for LDN-193189
InChIKey | XHBVYDAKJHETMP-UHFFFAOYSA-N |
New Products
Tubulysin D (2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin B 4-FLUOROPIPERIDINE Cyclobutanamine, 3,3-difluoro- (9CI) 5-Methyl-1-indanone CYCLOBUTYLAMINE HYDROCHLORIDE 3-N-BOC-(S)-AMINO BUTYRONITRILE 4,4-DIFLUOROCYCLOHEXYLAMINE HYDROCHLORIDE 3-(4-Chloro-butyryl) -1H-indole-5- carbonitrile 3-(S)-(+)- (1-Cyano-1,1- diphenylmethyl)- 1-tosylpyrrolidine (S)-4-(azidomethyl) -3-(3-fluoro-4- thiomorpholino phenyl) oxazolidin-2-one 1-(2,3-Dihydro- benzofuran-5-yl) -ethanone 7-chloro-1- (2-methyl-4- nitrobenzoyl)-3,4- dihydro-1H-benzo[b] azepin-5(2H)-one 5-(piperazin-1-yl) benzofuran-2- carboxamide 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrile 1H-Imidazole-4-carbonitrile (R)-methyl 2-formamido-3-(tritylthio)propanoate (R)-methyl 2-isocyano-3-(tritylthio)propanoate Salbutamol EP Impurity K / Salbutamol BP Impurity K Sertraline EP Impurity B / Sertraline BP Impurity B / 3,4-Dideschloro Sertraline HCl (USP) / cis-3,4-Dideschloro Sertraline HCl / Sertraline Phenyl Impurity HALOPERIDOL DECANOATE EP IMPURITY J | HALOPERIDOL UNDECANOATERelated products of tetrahydrofuran
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