LY2109761
- CAS NO.:700874-71-1
- Empirical Formula: C26H27N5O2
- Molecular Weight: 441.52
- MDL number: MFCD12923354
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-01 13:17:44
What is LY2109761?
Description
LY2157299 is a small molecule inhibitor of the TGF-
The Uses of LY2109761
LY 2109761 is a novel transforming growth factor beta receptor type I and type II dual inhibitor that is potentially used to treat and suppress pancreatic cancer.
What are the applications of Application
LY2109761 is a small molecule inhibitor of the TGF-β receptor type 1/type II kinases
References
[1]melisi d, ishiyama s, sclabas gm et al. ly2109761, a novel transforming growth factor beta receptor type i and type ii dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. mol cancer ther 2008; 7: 829-840.
[2]li hy, mcmillen wt, heap cr et al. optimization of a dihydropyrrolopyrazole series of transforming growth factor-beta type i receptor kinase domain inhibitors: discovery of an orally bioavailable transforming growth factor-beta receptor type i inhibitor as antitumor agent. j med chem 2008; 51: 2302-2306.
[3]xu y, tabe y, jin l et al. tgf-beta receptor kinase inhibitor ly2109761 reverses the anti-apoptotic effects of tgf-beta1 in myelo-monocytic leukaemic cells co-cultured with stromal cells. br j haematol 2008; 142: 192-201.
[4]zhang m, kleber s, rohrich m et al. blockade of tgf-beta signaling by the tgfbetar-i kinase inhibitor ly2109761 enhances radiation response and prolongs survival in glioblastoma. cancer res 2011; 71: 7155-7167.
[5]flechsig p, dadrich m, bickelhaupt s et al. ly2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of tgf-beta and bmp-associated proinflammatory and proangiogenic signals. clin cancer res 2012; 18: 3616-3627.
Properties of LY2109761
Boiling point: | 640.9±55.0 °C(Predicted) |
Density | 1.34 |
storage temp. | Store at -20°C |
solubility | ≥22.1 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
form | solid |
pka | 6.27±0.10(Predicted) |
color | White to yellow |
Safety information for LY2109761
Computed Descriptors for LY2109761
New Products
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