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HomeProduct name listLAUROLITSINE

LAUROLITSINE

LAUROLITSINE Structural

What is LAUROLITSINE?

Description

This noraporphiae alkaloid has been obtained from Litsea japonica and Neolitsea sericea and swells at 11 5-8°C before melting. It is dextrorotatory with [o:lbl + 102.5° (EtOH) and yields a picrate as yellow needles, m.p. 212°C (dec.) and a picrolonate, m.p. 239°C (dec.). The N-methyl derivative is identical with boldine.

The Uses of LAUROLITSINE

Laurolitsine is an alkaloid extracted from Polyalthia longifolia var. pendula.

Definition

ChEBI: An isoquinoline alkaloid that is noraporphine substituted by hydroxy groups at positions 2 and 9 and methoxy groups at positions 1 and 10. Isolated from Litsea glutinosa and Lindera chunii, exhibits inhibitory activity against HIV 1 integrase.

References

Nakasato, Nomura., Chem. Pharm. Bull., (Tokyo), 7, 780 (1959)
Kozuka., J. Ph arm. Soc., Japan, 82, 1567 (1962)
See also:
Johns, Lamberton., Austral. J. Chem., 20, 1277 (1967)

Properties of LAUROLITSINE

Melting point: 138-140 ºC
Boiling point: 453.15°C (rough estimate)
Density  1.313
refractive index  1.5100 (estimate)
solubility  Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form  Cryst.
pka 9.81±0.20(Predicted)
color  Off-white to pink

Safety information for LAUROLITSINE

Computed Descriptors for LAUROLITSINE

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