1,2-Distearoyl-sn-glycero-3-phosphocholine

Synonym(s):PC;DSPC;PC(18:0/18:0);L-α-Phosphatidylcholine, distearoyl;L-β,γ-Distearoyl-α-lecithin

CAS NO.：816-94-4
Empirical Formula: C44H88NO8P
Molecular Weight: 790.15
MDL number: MFCD00036905
EINECS: 212-440-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-20 11:41:24

1,2-Distearoyl-sn-glycero-3-phosphocholine Structural

What is 1,2-Distearoyl-sn-glycero-3-phosphocholine?

Description

1,2-Distearoyl-sn-glycero-3-PC (DSPC) is a phospholipid containing the saturated long-chain (18:0) stearic acid inserted at the sn-1 and sn-2 positions. It is commonly used in the generation of micelles, liposomes, and other types of artificial membranes.

Chemical properties

solid

The Uses of 1,2-Distearoyl-sn-glycero-3-phosphocholine

18:0 PC (DSPC) has been used:

in the microbubble monolayer preparation for biomolecule delivery studies into protoplasts
in the preparation of liposomes for immobilization studies
in the generation of porphyrin-phospholipid (PoP) liposomes for irinotecan (IRT) and doxorubicin delivery

Definition

ChEBI: A phosphatidylcholine 36:0 in which both phosphatidyl acyl groups are specified as stearoyl (octadecanoyl).

What are the applications of Application

1,2-Distearoyl-sn-glycero-3-phosphocholine is used to produce non-pyrogenic liposome capable of caging molecules

General Description

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is a phospholtidylcholine with alkyl chain comprising 18 carbons. It has phophatidylcholine head group and its structure is similar to 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC).

Biochem/physiol Actions

1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC) is used in combination with other members of phosphatidylcholine for the generation of mixed bilayer system. It is majorly used in conventional and stealth liposome preparation for drug delivery studies.

Properties of 1,2-Distearoyl-sn-glycero-3-phosphocholine

Melting point:	236°C(lit.)
storage temp.	-20°C
solubility	slightly sol. in Chloroform
form	powder to crystal
color	White to Almost white
BRN	3923978
Stability:	Stable. Incompatible with strong oxidizing agents.

Safety information for 1,2-Distearoyl-sn-glycero-3-phosphocholine

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H372:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention.