Ipragliflozin
- CAS NO.:761423-87-4
- Empirical Formula: C21H21FO5S
- Molecular Weight: 404.45
- MDL number: MFCD19443744
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-31 17:33:32
What is Ipragliflozin?
Description
Ipragliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor (IC50 = 7.4 nM in CHO cells expressing the human cotransporter). It is selective for SGLT2 over SGLT1, SGLT3, SGLT4, SGLT5, and SGLT6 (IC50s = 1.9, 30.4, 15.9, 0.46, and 10.4 μM, respectively). Ipragliflozin (0.1-3 mg/kg) decreases plasma levels of insulin and glucose in an oral glucose tolerance test in a mouse model of diabetes induced by high-fat diet, streptozotocin (STZ; ), and nicotinamide . It decreases plasma and hepatic IL-6, TNF-α, chemokine (C-C motif) ligand 2 (CCL2), and C-reactive protein (CRP) levels in the same model when administered at a dose of 3 mg/kg per day for 28 days.
The Uses of Ipragliflozin
Ipragliflozin is a potent and selective inhibitor of sodium-glucose cotransporter-2 (SGLT2) and can serve as a potential agent for the treatment of type 1 and type 2 diabetes.
Properties of Ipragliflozin
Melting point: | 155-157°C |
Boiling point: | 628.8±55.0 °C(Predicted) |
Density | 1.452 |
storage temp. | Refrigerator |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
color | White to Off-White |
Safety information for Ipragliflozin
Computed Descriptors for Ipragliflozin
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