Hypericin
Synonym(s):4,5,7,4′,5′,7′-Hexahydroxy-2,2′-dimethylnaphthodianthrone;Casein Kinase II Inhibitor XI;Cyclo werrol;Hypericin - CAS 548-04-9 - Calbiochem;Hypericum red
- CAS NO.:548-04-9
- Empirical Formula: C30H16O8
- Molecular Weight: 504.44
- MDL number: MFCD00016683
- EINECS: 208-941-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-07 08:52:35
What is Hypericin?
Description
An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities. Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects. It exerts broad spectrum phototoxic affects (IC50 = 140 - 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells. Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.
Chemical properties
Powder
The Uses of Hypericin
It was used as reference standard in determining hypericins in St. John′s Wort using HPLC method.
What are the applications of Application
Hypericin is a Protein Kinase C, CKII, MAP, Insulin R, EGFR, and PI-3 kinase inhibitor with antiviral activity.
Definition
ChEBI: Hypericin is a carbopolycyclic compound. It has a role as an antidepressant. It derives from a hydride of a bisanthene.
General Description
Produced by HWI Analytik
Exact content can be found on the certificate
Biological Activity
Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC 50 = 7.5 μ M) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.
Biochem/physiol Actions
Primary TargetPKC
storage
+4°C
Purification Methods
Crystallise hypericin from pyridine by addition of methanolic HCl. [Beilstein 8 IV 3761.]
References
1) Kubin et al., (2005) Hypericin – the facts about a controversial agent; Current Pharm. Des., 11 233 2) Theodossiou et al., (2009) The multifaceted photocytotoxic profile of hypericin; Mol. Pharmacol., 6 1775
Properties of Hypericin
Melting point: | 299-301°C |
Boiling point: | 1020.3±65.0 °C(Predicted) |
Density | 1.915±0.06 g/cm3(Predicted) |
RTECS | SF8472000 |
storage temp. | -20°C |
solubility | 1 M NaOH: 10 mg/mL |
pka | 6.91±0.20(Predicted) |
form | powder |
color | black |
Water Solubility | Soluble in ethanol, dimethyl sulfoxide, methanol, acetone, ethylmethylketone, pyridine and sodium hydroxide. Insoluble in water. |
Sensitive | Light Sensitive |
Merck | 14,4863 |
BRN | 1917913 |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
CAS DataBase Reference | 548-04-9(CAS DataBase Reference) |
Safety information for Hypericin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P501:Dispose of contents/container to..… |
Computed Descriptors for Hypericin
InChIKey | BTXNYTINYBABQR-UHFFFAOYSA-N |
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