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HomeProduct name listHypericin

Hypericin

Synonym(s):4,5,7,4′,5′,7′-Hexahydroxy-2,2′-dimethylnaphthodianthrone;Casein Kinase II Inhibitor XI;Cyclo werrol;Hypericin - CAS 548-04-9 - Calbiochem;Hypericum red

  • CAS NO.:548-04-9
  • Empirical Formula: C30H16O8
  • Molecular Weight: 504.44
  • MDL number: MFCD00016683
  • EINECS: 208-941-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 15:53:33
Hypericin Structural

What is Hypericin?

Description

An anthroquinone derivative that is naturally found in the flower of H. perforatum (St. John’s wort) and has antidepressant, antiviral, and anticancer activities. Hypericin inhibits neuronal uptake of serotonin, norepinephrine, dopamine, GABA and L-glutamate, contributing to its antidepressant effects. It exerts broad spectrum phototoxic affects (IC50 = 140 - 1,570 nM) through induction of apoptotic signaling and formation of reactive oxygen species (ROS) in cancer cells. Hypericin also has in vitro activity, which can be enhanced with photo-activation, against a variety of viruses including HIV, influenza virus, hepatitis C, murine cytolomegalovirus, and herpes viruses.

Chemical properties

Powder

The Uses of Hypericin

It was used as reference standard in determining hypericins in St. John′s Wort using HPLC method.

What are the applications of Application

Hypericin is a Protein Kinase C, CKII, MAP, Insulin R, EGFR, and PI-3 kinase inhibitor with antiviral activity.

Definition

ChEBI: Hypericin is a carbopolycyclic compound. It has a role as an antidepressant. It derives from a hydride of a bisanthene.

General Description

Produced by HWI Analytik
Exact content can be found on the certificate

Biological Activity

Photosensitive antiviral, anticancer and antidepressant agent derived from Hypericum perforatum (St John's wort). Inactivates enveloped viruses (including HIV), inhibits tyrosine kinases (IC 50 = 7.5 μ M) and is preferentially cytotoxic to tumor cells upon stimulation by visible light.

Biochem/physiol Actions

Primary TargetPKC

storage

+4°C

Purification Methods

Crystallise hypericin from pyridine by addition of methanolic HCl. [Beilstein 8 IV 3761.]

References

1) Kubin et al., (2005) Hypericin – the facts about a controversial agent; Current Pharm. Des., 11 233 2) Theodossiou et al., (2009) The multifaceted photocytotoxic profile of hypericin; Mol. Pharmacol., 6 1775

Properties of Hypericin

Melting point: 299-301°C
Boiling point: 1020.3±65.0 °C(Predicted)
Density  1.915±0.06 g/cm3(Predicted)
RTECS  SF8472000
storage temp.  -20°C
solubility  1 M NaOH: 10 mg/mL
pka 6.91±0.20(Predicted)
form  powder
color  black
Water Solubility  Soluble in ethanol, dimethyl sulfoxide, methanol, acetone, ethylmethylketone, pyridine and sodium hydroxide. Insoluble in water.
Sensitive  Light Sensitive
Merck  14,4863
BRN  1917913
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
CAS DataBase Reference 548-04-9(CAS DataBase Reference)

Safety information for Hypericin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501:Dispose of contents/container to..…

Computed Descriptors for Hypericin

InChIKey BTXNYTINYBABQR-UHFFFAOYSA-N

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