Homovanillic acid

Synonym(s):4-Hydroxy-3-methoxyphenylacetic acid;HVA

CAS NO.：306-08-1
Empirical Formula: C9H10O4
Molecular Weight: 182.17
MDL number: MFCD00004350
EINECS: 206-176-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-10-16 17:43:51

What is Homovanillic acid?

Description

Homovanillic acid (HVA) is a dopamine metabolite. It is formed via deamination of dopamine by monoamine oxidase (MAO) to produce 3,4-dihydroxyphenylacetic acid (DOPAC; ) followed by DOPAC metabolism by catechol-O-methyltransferase (COMT). HVA undergoes hydrogen peroxide-dependent oxidation in the presence of horseradish peroxidase to form a fluorescent dimer that displays excitation/emission maxima of 312/420 nm, respectively. It has been used to quantify hydrogen peroxide production in macrophages and neutrophils.

Chemical properties

white to beige crystalline powder

The Uses of Homovanillic acid

Fluorimetric reagent and major catecholamine metaboliteHomovanillic acid is used as a reagent in the determination of oxidative enzymes. It is associated with dopamine levels in the brain. Its presence supports a diagnosis of neuroblastoma and malignant pheochromocytoma.

The Uses of Homovanillic acid

A neuroendocrine tumor marker. Dihydroxyphenylacetic Acid (DOPAC) metabolite.

What are the applications of Application

Homovanillic acid is Fluorimetric reagent and major catecholamine metabolite

Definition

ChEBI: A monocarboxylic acid that is the 3-O-methyl ether of (3,4-dihydroxyphenyl)acetic acid. It is a catecholamine metabolite.

Biological Activity

Fluorimetric reagent and major catecholamine metabolite. Used for fluorimetric determination of oxidative enzymes including glucose oxidase.

storage

+4°C

Properties of Homovanillic acid

Melting point:	142-145 °C(lit.)
Boiling point:	235.56°C (rough estimate)
Density	1.1634 (rough estimate)
refractive index	1.4209 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
pka	4.39±0.10(Predicted)
form	Crystalline Powder
color	White to beige
Water Solubility	soluble
Merck	14,4740
BRN	2213447
Stability:	Hygroscopic
CAS DataBase Reference	306-08-1(CAS DataBase Reference)
NIST Chemistry Reference	Benzeneacetic acid, 4-hydroxy-3-methoxy-(306-08-1)
EPA Substance Registry System	Homovanillic acid (306-08-1)

Safety information for Homovanillic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P280:Wear protective gloves/protective clothing/eye protection/face protection. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.